Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWIX23)

Drug Name
Metaraminol Drug Info
Synonyms
Araminol; Hydroxynorephedrine; Isophenylephrine; Metaradrin; Metaradrine; Metaraminolum; Pressonex; Pressorol; Icoral B; Metaraminolum [Latin]; Aramine (TN); L-Metaraminol; M-Hydroxy norephedrine; M-Hydroxynorephedrine; M-Hydroxyphenylpropanolamine; M-Hydroxypropadrine; Meta-Hydroxynorephedrine; Metaraminol (INN); Metaraminol [INN:BAN]; Metaraminolum [INN-Latin]; Alpha-(1-Aminoethyl)-3-hydroxybenzenemethanol; Alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol; Alpha-(m-Hydroxyphenyl)-beta-aminopropanol; M-Hydroxy-alpha-(1-aminoethyl)-benzyl alcohol; Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-(9CI); (-)-Erythro-metaraminol; 1-(m-Hydroxyphenyl)-2-amino-1-propanol; 1-Metaraminol; 1-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol; 2-Amino-1-(m-hydroxyphenyl)-1-propanol; 3-Hydroxyphenylisopropanolamine; 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
5906
ChEBI ID
CHEMBL1201319
CAS Number
CAS 54-49-9
TTD Drug ID
D04EYC
VARIDT Drug ID
DR01169

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 1.95 1.16e-2 19/20 (95%) NSDHL;HSD17B7;SOAT1;...
PPAR signaling pathway 1.92 1.16e-2 66/74 (89.19%) HMGCS2;CD36;FABP4;...
Fatty acid elongation 1.83 4.24e-2 19/27 (70.37%) ELOVL5;HACD1;ECHS1;...
Adipocytokine signaling pathway 1.81 4.92e-2 64/69 (92.75%) NPY;CD36;ACSL3;...
Morphine addiction 1.78 4.86e-2 80/91 (87.91%) GNG11;GNAS;GABRA2;...
Glycine, serine and threonine metabolism -1.97 0.00e+0 31/40 (77.5%) GLDC;GNMT;BPGM;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 24H