Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWJ4TQ)

Drug Name
Isbufylline Drug Info
Synonyms TE/06
Cross-matching ID
PubChem CID
65681
CAS Number
CAS 90162-60-0
TTD Drug ID
D05VAA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.05 0.00e+0 56/67 (83.58%) FBP1;PGAM1;TPI1;...
Cysteine and methionine metabolism 1.96 6.48e-3 43/50 (86%) ADI1;PSAT1;BHMT;...
Lysine degradation 1.93 4.32e-3 51/63 (80.95%) SUV39H1;DLD;DLST;...
Arginine and proline metabolism 1.86 1.30e-2 39/50 (78%) GATM;LAP3;ALDH9A1;...
AGE-RAGE signaling pathway in diabetic complications 1.86 1.04e-2 97/100 (97%) TGFBR2;PIK3R1;PLCB1;...
African trypanosomiasis 1.84 1.08e-2 32/37 (86.49%) PLCB1;F2RL1;VCAM1;...
Tryptophan metabolism 1.83 1.30e-2 35/42 (83.33%) AOX1;DLD;ALDH8A1;...
Mismatch repair 1.78 2.43e-2 22/23 (95.65%) MSH6;PCNA;RFC3;...
DNA replication 1.76 3.46e-2 34/36 (94.44%) POLE3;PCNA;RFC3;...
Proteasome -2.02 6.37e-3 44/46 (95.65%) PSMB1;PSMC5;PSME4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 3.33uM 24H