Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWL4MI)

Drug Name
SSR-69071 Drug Info
Synonyms
SSR 69071; 344930-95-6; SSR69071; DSSTox_RID_82301; DSSTox_CID_27368; DSSTox_GSID_47368; MLS006010264; SCHEMBL4295477; CHEMBL1354892; DTXSID1047368; CTK8E8740; CHEBI:93283; MolPort-023-276-460; HMS3269M07; ZINC1490807; Tox21_300247; AKOS024457139; NCGC00254231-01; NCGC00167751-02; NCGC00167751-01; NCGC00167751-03; SMR001822512; RT-015782; LS-191133; FT-0724044; CAS-344930-95-6; J-019626; BRD-K72895815-001-01-4
Cross-matching ID
PubChem CID
9872438
ChEBI ID
CHEMBL93283
CAS Number
CAS 344930-95-6
TTD Drug ID
D0B3MV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.32 0.00e+0 48/60 (80%) HMOX1;MT1M;MT1X;...
Ferroptosis 1.96 1.03e-2 36/41 (87.8%) HMOX1;GCLM;SLC7A11;...
Antigen processing and presentation 1.94 1.03e-2 60/78 (76.92%) HSPA6;HSPA1A;HSPA8;...
Legionellosis 1.94 7.76e-3 51/57 (89.47%) HSPA6;HSPA1A;HSPA8;...
Proteasome 1.82 1.86e-2 44/46 (95.65%) PSMD2;PSMD11;PSMD14;...
Fluid shear stress and atherosclerosis 1.79 2.93e-2 123/139 (88.49%) HMOX1;SQSTM1;VEGFA;...
Protein processing in endoplasmic reticulum 1.78 2.95e-2 127/171 (74.27%) HSPA6;HSPA1A;HSPA8;...
Estrogen signaling pathway 1.74 4.14e-2 119/137 (86.86%) HSPA6;HSPA1A;HSPA8;...
IL-17 signaling pathway 1.73 4.48e-2 84/94 (89.36%) FOSL1;S100A9;S100A8;...
PPAR signaling pathway -1.80 1.92e-2 66/74 (89.19%) SLC27A2;EHHADH;FADS2;...
Propanoate metabolism -1.81 2.06e-2 30/34 (88.24%) SUCLA2;ACAT1;ACSS3;...
Peroxisome -1.83 1.60e-2 72/82 (87.8%) PEX11B;ECH1;CAT;...
Fat digestion and absorption -1.86 1.15e-2 35/43 (81.4%) MTTP;AGPAT1;CD36;...
Valine, leucine and isoleucine degradation -1.87 1.20e-2 42/48 (87.5%) IVD;PCCA;ACADSB;...
Terpenoid backbone biosynthesis -1.87 1.28e-2 18/22 (81.82%) MVD;HMGCS2;PDSS2;...
Fatty acid degradation -1.90 1.92e-2 40/43 (93.02%) ALDH1B1;ALDH9A1;ACAT1;...
Steroid biosynthesis -2.05 9.61e-3 19/20 (95%) DHCR7;FDFT1;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H