Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWN09H)

Drug Name
Istaroxime Drug Info
Synonyms
Debio-0614; PST-2107; PST-2744; PST-2915; ST-2744; Digitalis-like compounds, Sigma-Tau; Sodium/potassium-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/Debiopharm; Na(+)-/K(+)-ATPase inhibitors (cardiac failure), Sigma-Tau; Na(+)-/K(+)-ATPase inhibitors (infusion, cardiac failure), Sigma-Tau/ Debiopharm
Cross-matching ID
PubChem CID
9841834
CAS Number
CAS 203737-93-3
TTD Drug ID
D06HIO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.41 0.00e+0 84/94 (89.36%) CXCL8;S100A9;CXCL1;...
Spliceosome 2.24 0.00e+0 101/150 (67.33%) EIF4A3;SRSF1;PRPF19;...
Legionellosis 2.08 0.00e+0 51/57 (89.47%) CXCL8;CXCL1;CXCL2;...
Epithelial cell signaling in Helicobacter pylori infect... 2.05 0.00e+0 62/70 (88.57%) CXCL8;CXCL1;CXCL2;...
Rheumatoid arthritis 2.00 2.71e-3 78/93 (83.87%) CXCL8;CXCL1;CXCL2;...
NF-kappa B signaling pathway 1.87 2.71e-2 90/104 (86.54%) CXCL8;CXCL1;CXCL2;...
Malaria 1.83 3.68e-2 44/50 (88%) CXCL8;IL6;TLR4;...
TNF signaling pathway 1.79 3.73e-2 103/112 (91.96%) CXCL1;CXCL2;IL6;...
Leishmaniasis 1.72 4.84e-2 67/77 (87.01%) TLR4;C3;FOS;...
Phagosome 1.71 4.61e-2 118/152 (77.63%) TLR4;ATP6V1D;CD14;...
Protein export 1.71 4.40e-2 17/23 (73.91%) OXA1L;SRPRB;SRP72;...
Fructose and mannose metabolism -1.79 2.24e-2 30/33 (90.91%) PFKP;TKFC;GMPPA;...
Galactose metabolism -1.83 1.22e-2 26/31 (83.87%) LALBA;PFKP;GALE;...
Protein digestion and absorption -2.06 0.00e+0 78/103 (75.73%) CELA3B;COL8A1;CPB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H