General Information of Drug (ID: DMWN2EC)

Drug Name
ORG-25935 Drug Info
Synonyms Cis-N-(6-Methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)-N-methylglycine hydrochloride
Cross-matching ID
PubChem CID
11717074
ChEBI ID
CHEMBL4228124
CAS Number
CAS 1147011-84-4
TTD Drug ID
D0LT0U
VARIDT Drug ID
DR01107

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Primary immunodeficiency 2.18 0.00e+0 33/38 (86.84%) LCK;CD8A;IL2RG;...
Mucin type O-glycan biosynthesis 1.94 9.38e-3 20/36 (55.56%) GALNT10;B4GALT5;GCNT3;...
Ribosome -1.66 4.63e-2 113/158 (71.52%) RPS20;RPL28;RPL32;...
Drug metabolism -1.67 4.66e-2 78/151 (51.66%) GSTM2;CYP2C8;ADH7;...
PPAR signaling pathway -1.70 3.71e-2 66/74 (89.19%) FABP7;SCP2;RXRG;...
Folate biosynthesis -1.71 3.50e-2 23/26 (88.46%) MOCS1;PTS;GPHN;...
Steroid hormone biosynthesis -1.72 3.53e-2 43/61 (70.49%) HSD17B8;CYP7A1;CYP3A7;...
Cholesterol metabolism -1.73 3.75e-2 44/50 (88%) ANGPTL8;VDAC1;STARD3;...
Linoleic acid metabolism -1.78 2.33e-2 21/29 (72.41%) CYP3A4;CYP2E1;PLA2G3;...
Fatty acid elongation -1.84 1.18e-2 19/27 (70.37%) ACAA2;HACD3;HACD2;...
Proximal tubule bicarbonate reclamation -1.93 2.65e-3 21/23 (91.3%) PCK1;CA4;GLUD1;...
Bile secretion -1.94 3.03e-3 68/90 (75.56%) SCARB1;ABCB4;UGT2A3;...
Fat digestion and absorption -1.94 3.53e-3 35/43 (81.4%) PLA2G3;SCARB1;PLA2G2A;...
Primary bile acid biosynthesis -1.95 2.12e-3 15/17 (88.24%) CYP27A1;AKR1C4;SCP2;...
Nitrogen metabolism -1.99 0.00e+0 16/17 (94.12%) CA3;CA4;GLUL;...
Metabolism of xenobiotics by cytochrome P450 -1.99 0.00e+0 49/77 (63.64%) GSTM2;AKR7A3;ADH7;...
Retinol metabolism -2.18 0.00e+0 41/68 (60.29%) CYP1A2;CYP2A6;ADH1A;...
Pentose and glucuronate interconversions -2.20 0.00e+0 17/34 (50%) GUSB;UGP2;UGT2A3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H