Details of the Drug Pharmacogenomic Perturbation Atlas

Tazemetostat Drug Info

EPZ-6438; 1403254-99-8; EPZ6438; UNII-Q40W93WPE1; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; Q40W93WPE1; EPZ 6438; E7438; (1,1'-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-

Cross-matching ID

PubChem CID

66558664

ChEBI ID

CHEMBL3414621

CAS Number

CAS 1403254-99-8

TTD Drug ID

D00EQL

ACDINA Drug ID

D01463

General Information of Drug (ID: DMWP1BH)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.13	9.65e-3	19/20 (95%)	SQLE;MSMO1;DHCR24;...
PPAR signaling pathway	1.89	3.38e-2	66/74 (89.19%)	HMGCS1;DBI;LPL;...
Terpenoid backbone biosynthesis	1.82	3.86e-2	18/22 (81.82%)	HMGCS1;IDI1;ACAT2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.37uM - 10uM	24H

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
K-562	CVCL_0004	Homo sapiens	0.01uM - 10uM	24H

Multiple myeloma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
KMS-34	CVCL_1333	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.37uM - 10uM	24H

Lymph node

Burkitt lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BJAB	CVCL_5711	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Diffuse large B-cell lymphoma

Mantle cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MINO	CVCL_4965	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Peripheral blood

Acute B-lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NALM-6	CVCL_0092	Homo sapiens	0.01uM - 10uM	24H

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H

Skin

Melanoma