Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWPT8J)

Drug Name
Oxibendazole Drug Info
Synonyms Oxibendazole, GlaxoSmithKline
Cross-matching ID
PubChem CID
4622
ChEBI ID
CHEMBL1087630
CAS Number
CAS 20559-55-1
TTD Drug ID
D0B9GM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.01 1.34e-2 44/46 (95.65%) PSMA7;PSMB7;PSMD6;...
Salmonella infection 2.01 6.68e-3 198/249 (79.52%) S100A10;TUBB2A;PODXL;...
ErbB signaling pathway 1.85 4.90e-2 79/85 (92.94%) EREG;JUN;PRKCA;...
MAPK signaling pathway 1.75 4.90e-2 272/294 (92.52%) HSPA8;EREG;JUN;...
Natural killer cell mediated cytotoxicity 1.75 4.54e-2 99/131 (75.57%) MICB;PRKCA;KLRK1;...
Morphine addiction 1.74 4.13e-2 80/91 (87.91%) GABRP;PRKCA;ADCY7;...
Antigen processing and presentation 1.73 4.79e-2 60/78 (76.92%) HSPA8;HSP90AA1;HSP90AB1;...
IL-17 signaling pathway 1.72 4.83e-2 84/94 (89.36%) FOSL1;HSP90AA1;JUN;...
Ribosome biogenesis in eukaryotes 1.69 4.99e-2 52/108 (48.15%) NVL;NMD3;POP1;...
Mismatch repair -1.61 4.35e-2 22/23 (95.65%) RFC4;POLD3;POLD1;...
Drug metabolism -1.65 3.40e-2 78/151 (51.66%) GSTM5;GSTM2;ADH6;...
Fat digestion and absorption -1.66 3.25e-2 35/43 (81.4%) NPC1L1;FABP1;FABP2;...
Pentose and glucuronate interconversions -1.70 2.07e-2 17/34 (50%) GUSB;SORD;DCXR;...
Butanoate metabolism -1.74 1.26e-2 23/28 (82.14%) ECHS1;BDH1;ACADS;...
Phenylalanine metabolism -1.76 8.78e-3 14/17 (82.35%) GOT1;MAOB;DDC;...
Primary bile acid biosynthesis -1.77 9.65e-3 15/17 (88.24%) SLC27A5;ACOT8;AMACR;...
Glutathione metabolism -1.77 8.43e-3 43/57 (75.44%) PRDX6;RRM2;GGT5;...
Histidine metabolism -1.78 8.62e-3 16/22 (72.73%) MAOB;ASPA;ALDH3A2;...
Tyrosine metabolism -1.83 1.97e-3 30/36 (83.33%) TYR;ADH1A;GOT1;...
DNA replication -1.83 2.30e-3 34/36 (94.44%) FEN1;RFC4;POLD3;...
Arachidonic acid metabolism -1.83 2.76e-3 48/61 (78.69%) GGT5;PLA2G6;PTGDS;...
Metabolism of xenobiotics by cytochrome P450 -1.93 3.45e-3 49/77 (63.64%) GSTM5;GSTM2;ADH6;...
Fatty acid degradation -2.02 2.30e-3 40/43 (93.02%) CPT2;ADH6;ACOX1;...
Valine, leucine and isoleucine degradation -2.02 3.45e-3 42/48 (87.5%) ECHS1;AUH;IVD;...
Steroid hormone biosynthesis -2.13 0.00e+0 43/61 (70.49%) CYP17A1;CYP2E1;CYP11B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H