Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWQK9H)

Drug Name
Benperidol Drug Info
Synonyms
BENPERIDOL; Anquil; 2062-84-2; Glianimon; Frenactil; Frenactyl; Concilium; Benzoperidol; McN-JR-4584; Benzperidol; Glianimon mite; R-4584; Anquil (VAN); Benperidolo [DCIT]; Benperidol hydrochloride; Benzeridol; Benperidolum [INN-Latin]; R 4584; Benperidol [USAN:INN:BAN]; McN-JR 4584; CB 8089; UNII-97O6X78C53; 8089 C. B.; EINECS 218-172-2; NSC 170982; BRN 0900981; 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1h-benzo[d]imidazol-2(3h)-one; 8089 C.B.; C22H24FN3O2; FEBOTPHFXYHVPL-UHFFFAOYSA-N; NSC170982; 2H-Benzimidazol-2-one, 1-[1-[4
Cross-matching ID
PubChem CID
16363
ChEBI ID
CHEMBL93403
CAS Number
CAS 2062-84-2
TTD Drug ID
D0X7QQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Chagas disease 2.00 2.02e-2 93/102 (91.18%) CCL5;TLR4;GNAQ;...
Chronic myeloid leukemia 2.00 1.35e-2 72/76 (94.74%) CTBP2;MYC;E2F2;...
Toll-like receptor signaling pathway 1.94 1.01e-2 94/104 (90.38%) CXCL10;CXCL9;CCL5;...
Toxoplasmosis 1.91 1.08e-2 103/112 (91.96%) TLR4;HSPA6;LAMB1;...
Graft-versus-host disease 1.88 1.12e-2 32/42 (76.19%) PRF1;HLA-DPA1;HLA-DRB1;...
Salmonella infection 1.86 1.16e-2 198/249 (79.52%) TLR4;MYC;PODXL;...
Amoebiasis 1.80 2.02e-2 99/102 (97.06%) TLR4;LAMB1;PRKACB;...
Influenza A 1.80 1.80e-2 156/172 (90.7%) CXCL10;CCL5;TLR4;...
Chemokine signaling pathway 1.76 2.21e-2 163/192 (84.9%) CXCL10;CXCL9;CCL5;...
Yersinia infection 1.75 2.25e-2 120/137 (87.59%) TLR4;FYB1;GNAQ;...
Cell adhesion molecules 1.74 2.18e-2 118/148 (79.73%) ICAM1;NCAM1;CD2;...
Pancreatic cancer 1.74 2.02e-2 75/76 (98.68%) E2F2;CDC42;TGFBR2;...
Small cell lung cancer 1.74 1.89e-2 90/92 (97.83%) MYC;LAMB1;E2F2;...
TNF signaling pathway 1.73 1.86e-2 103/112 (91.96%) CXCL10;CCL5;JAG1;...
Cortisol synthesis and secretion 1.73 1.83e-2 58/65 (89.23%) PRKACB;GNAQ;ITPR1;...
Legionellosis 1.72 1.80e-2 51/57 (89.47%) TLR4;HSPA6;CXCL1;...
Allograft rejection 1.72 1.78e-2 32/38 (84.21%) PRF1;HLA-DPA1;HLA-DRB1;...
Gap junction 1.72 1.69e-2 72/88 (81.82%) PDGFC;PRKACB;GNAQ;...
Hepatitis C 1.70 1.86e-2 139/157 (88.54%) CXCL10;MYC;E2F2;...
Antigen processing and presentation 1.70 1.78e-2 60/78 (76.92%) HSPA6;CD8A;HSPA8;...
Adherens junction 1.70 1.76e-2 63/71 (88.73%) ACTN1;CDC42;TGFBR2;...
Pathways in cancer 1.69 1.74e-2 474/531 (89.27%) CTBP2;MYC;IL7R;...
Long-term depression 1.69 1.89e-2 55/60 (91.67%) GNAQ;ITPR1;GNAS;...
Inflammatory bowel disease 1.68 1.87e-2 58/65 (89.23%) TLR4;TLR2;HLA-DPA1;...
Renal cell carcinoma 1.68 1.90e-2 68/69 (98.55%) PAK1;CDC42;AKT3;...
Viral myocarditis 1.67 2.07e-2 53/60 (88.33%) PRF1;ICAM1;EIF4G1;...
Herpes simplex virus 1 infection 1.67 2.00e-2 165/498 (33.13%) CCL5;TLR2;NFKBIA;...
Lipid and atherosclerosis 1.67 2.29e-2 190/215 (88.37%) CCL5;TLR4;HSPA6;...
Cushing syndrome 1.67 2.26e-2 125/155 (80.65%) FZD2;PRKACB;GNAQ;...
Pathogenic Escherichia coli infection 1.65 2.32e-2 152/197 (77.16%) TLR4;PAK1;CDC42;...
Steroid biosynthesis -1.69 3.95e-2 19/20 (95%) LSS;CYP24A1;LIPA;...
Pentose and glucuronate interconversions -1.69 4.34e-2 17/34 (50%) UGT2B15;UGDH;AKR1A1;...
Steroid hormone biosynthesis -1.69 4.84e-2 43/61 (70.49%) CYP3A4;HSD17B8;SULT1E1;...
Cardiac muscle contraction -1.77 3.23e-2 64/87 (73.56%) SLC9A7;MYL4;CACNB1;...
Glycerolipid metabolism -1.80 2.37e-2 44/61 (72.13%) ALDH2;DGKD;DGKA;...
Oxidative phosphorylation -2.02 3.23e-3 93/133 (69.92%) NDUFS8;ATP6V1E1;ATP6V0A1;...
Mineral absorption -2.21 0.00e+0 48/60 (80%) SLC39A4;SLC30A1;HMOX1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H