Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWSC5L)

Drug Name
L-778123 Drug Info
Synonyms
183499-57-2; L-778123; UNII-31ZXM8ZKQ3; 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE; 31ZXM8ZKQ3; CHEMBL279433; 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile; L-778123 free base; 4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile; 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}imidazol-1-yl)methyl]benzonitrile; SCHEMBL1683541; AC1L50Q0; CTK7C7787; 1s63; 1s64; BDBM50097071; ZINC53070632
Cross-matching ID
PubChem CID
216454
ChEBI ID
CHEMBL279433
CAS Number
CAS 183499-57-2
TTD Drug ID
D0Q5VW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway -1.64 4.24e-2 84/94 (89.36%) MAP3K7;CHUK;CXCL1;...
Glycosaminoglycan biosynthesis -1.65 3.98e-2 40/58 (68.97%) B4GALT1;B3GAT3;EXT1;...
Transcriptional misregulation in cancer -1.68 3.27e-2 158/192 (82.29%) SS18;SP1;ATF1;...
Pentose phosphate pathway -1.69 2.91e-2 25/30 (83.33%) PFKL;PRPS1;TKTL1;...
Mismatch repair -1.69 2.97e-2 22/23 (95.65%) POLD2;SSBP1;EXO1;...
Hepatitis C -1.69 2.79e-2 139/157 (88.54%) YWHAH;NFKBIA;PIK3CA;...
Proteasome -1.72 2.18e-2 44/46 (95.65%) PSMB5;PSMD1;PSMB7;...
Starch and sucrose metabolism -1.73 1.67e-2 25/36 (69.44%) GYG1;ENPP1;MGAM;...
Cell cycle -1.77 1.04e-2 110/124 (88.71%) TFDP2;ANAPC1;SMC3;...
Ferroptosis -1.77 1.17e-2 36/41 (87.8%) SLC3A2;SLC39A14;SAT1;...
RNA transport -1.79 1.19e-2 128/186 (68.82%) NUP107;SRRM1;POP5;...
Arginine and proline metabolism -1.81 1.04e-2 39/50 (78%) GOT2;ALDH2;ARG2;...
Fructose and mannose metabolism -1.81 1.25e-2 30/33 (90.91%) HK3;PFKFB3;PFKM;...
Steroid biosynthesis -1.82 1.57e-2 19/20 (95%) DHCR24;EBP;CYP51A1;...
Ribosome biogenesis in eukaryotes -1.85 1.04e-2 52/108 (48.15%) MPHOSPH10;HEATR1;BMS1;...
Epstein-Barr virus infection -1.88 5.22e-3 189/202 (93.56%) E2F1;MAP2K3;DDX58;...
DNA replication -2.20 0.00e+0 34/36 (94.44%) MCM3;PRIM1;POLD2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 3.33uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H