General Information of Drug (ID: DMWTAOI)

Drug Name
Estramustine Drug Info
Synonyms
Estramustina; Estramustinum; Emcyt (TN); Estramustine (USAN/INN); Estradiol 3-[bis(2-chloroethyl)carbamate]; Ro-22-2296/000; Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 3-[bis(2-chloroethyl)carbamate]; [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate; (17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate; 17.beta.-Estradiol 3-[bis(2-chloroethyl)carbamate]
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
259331
ChEBI ID
CHEMBL1575
CAS Number
CAS 2998-57-4
TTD Drug ID
D03SRY
VARIDT Drug ID
DR00522
INTEDE Drug ID
DR0645
ACDINA Drug ID
D00247

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.83 1.11e-1 34/36 (94.44%) POLE3;RFC2;PRIM1;...
Neutrophil extracellular trap formation 1.80 7.78e-2 101/189 (53.44%) CYBB;CTSG;CYBA;...
Progesterone-mediated oocyte maturation 1.77 8.15e-2 75/100 (75%) KRAS;CCNA2;AKT3;...
Oxytocin signaling pathway 1.67 2.31e-1 128/154 (83.12%) MYLK;MEF2C;KRAS;...
Nucleotide excision repair 1.64 2.51e-1 40/47 (85.11%) POLE3;RAD23B;RFC2;...
Oocyte meiosis 1.64 2.09e-1 90/129 (69.77%) PTTG1;PLK1;PPP2R1A;...
Staphylococcus aureus infection 1.58 2.99e-1 72/95 (75.79%) DEFB1;KRT10;HLA-DMB;...
Aldosterone-regulated sodium reabsorption 1.57 2.85e-1 34/37 (91.89%) KRAS;SCNN1A;PRKCB;...
Spliceosome 1.57 2.64e-1 101/150 (67.33%) PRPF4;LSM7;HSPA2;...
Retinol metabolism 1.53 3.27e-1 41/68 (60.29%) ALDH1A3;ALDH1A1;ALDH1A2;...
Proximal tubule bicarbonate reclamation 1.53 3.04e-1 21/23 (91.3%) SLC4A4;CA2;ATP1A1;...
Fc epsilon RI signaling pathway 1.52 3.03e-1 57/68 (83.82%) FCER1G;KRAS;ALOX5;...
Leukocyte transendothelial migration 1.50 3.24e-1 90/114 (78.95%) CYBB;CDC42;CYBA;...
Retrograde endocannabinoid signaling 1.49 3.14e-1 118/148 (79.73%) PRKCB;GABRP;GNG4;...
Oxidative phosphorylation 1.48 3.19e-1 93/133 (69.92%) ATP5MC2;PPA2;ATP5MC1;...
GABAergic synapse 1.47 3.28e-1 76/89 (85.39%) SRC;GLUL;PRKCB;...
Fc gamma R-mediated phagocytosis 1.46 3.26e-1 79/97 (81.44%) MARCKS;PAK1;CDC42;...
Apelin signaling pathway 1.46 3.10e-1 117/137 (85.4%) MYLK;ACTA2;MEF2C;...
Dopaminergic synapse 1.46 3.05e-1 115/132 (87.12%) ARRB2;AKT3;PRKCB;...
T cell receptor signaling pathway 1.46 2.92e-1 93/104 (89.42%) PAK1;CDC42;KRAS;...
Mismatch repair 1.45 2.84e-1 22/23 (95.65%) RFC2;LIG1;SSBP1;...
VEGF signaling pathway 1.45 2.80e-1 50/59 (84.75%) CDC42;KRAS;HSPB1;...
C-type lectin receptor signaling pathway 1.45 2.69e-1 93/104 (89.42%) PAK1;FCER1G;KRAS;...
Tyrosine metabolism 1.44 2.69e-1 30/36 (83.33%) TYRP1;ALDH3B1;DCT;...
Circadian entrainment 1.42 3.05e-1 85/97 (87.63%) PER2;PER3;GUCY1B1;...
Glutamatergic synapse 1.40 3.31e-1 97/114 (85.09%) GLUL;HOMER1;PRKCB;...
Long-term depression 1.40 3.21e-1 55/60 (91.67%) KRAS;GUCY1B1;PRKCB;...
Diabetic cardiomyopathy 1.40 3.16e-1 162/203 (79.8%) COL1A2;CYBB;CYBA;...
Steroid biosynthesis 1.38 3.50e-1 19/20 (95%) CYP51A1;CYP24A1;LSS;...
Phagosome 1.38 3.47e-1 118/152 (77.63%) CYBB;CYBA;CTSS;...
Cell adhesion molecules -1.15 5.54e-1 118/148 (79.73%) SELE;PVR;CADM1;...
Cortisol synthesis and secretion -1.16 5.55e-1 58/65 (89.23%) PDE8B;NR0B1;PLCB4;...
Prostate cancer -1.21 5.24e-1 93/97 (95.88%) CCNE1;PTEN;IGF1R;...
Linoleic acid metabolism -1.22 5.28e-1 21/29 (72.41%) CYP2J2;PLA2G4A;PLA2G2F;...
Caffeine metabolism -1.23 5.10e-1 5/6 (83.33%) NAT1;CYP2A6
Hematopoietic cell lineage -1.24 4.90e-1 90/99 (90.91%) HLA-DRB1;THPO;CD8A;...
Antigen processing and presentation -1.24 4.97e-1 60/78 (76.92%) HLA-F;CTSB;HSP90AB1;...
Gastric cancer -1.25 5.10e-1 122/149 (81.88%) CCNE1;FZD2;CSNK1A1;...
Chronic myeloid leukemia -1.27 4.66e-1 72/76 (94.74%) SHC1;TGFB2;RUNX1;...
Cytokine-cytokine receptor interaction -1.27 4.72e-1 246/295 (83.39%) IL15RA;CD27;TNFSF18;...
Nicotinate and nicotinamide metabolism -1.28 4.79e-1 25/35 (71.43%) NMRK2;NADSYN1;QPRT;...
Valine, leucine and isoleucine degradation -1.30 4.46e-1 42/48 (87.5%) BCAT2;ACADSB;HADHB;...
Basal transcription factors -1.33 3.84e-1 37/45 (82.22%) TBP;GTF2E1;CCNH;...
Glycerophospholipid metabolism -1.33 4.04e-1 71/98 (72.45%) LPCAT4;PLA1A;AGPAT4;...
Pathways in cancer -1.33 4.18e-1 474/531 (89.27%) IL15RA;DVL2;TRAF3;...
Small cell lung cancer -1.35 4.04e-1 90/92 (97.83%) CDKN1B;CCNE2;ITGA6;...
Complement and coagulation cascades -1.35 4.20e-1 76/85 (89.41%) CFHR5;C9;TFPI;...
Arginine biosynthesis -1.35 4.33e-1 17/22 (77.27%) CPS1;ASS1;ARG2
Steroid hormone biosynthesis -1.37 4.19e-1 43/61 (70.49%) AKR1C4;UGT2B4;CYP7A1;...
Regulation of lipolysis in adipocytes -1.40 3.59e-1 52/55 (94.55%) TSHR;ADCY1;CGA;...
JAK-STAT signaling pathway -1.40 3.70e-1 146/162 (90.12%) IFNA2;STAT3;IFNA5;...
Fatty acid degradation -1.40 4.00e-1 40/43 (93.02%) ADH1B;GCDH;ACADSB;...
SNARE interactions in vesicular transport -1.40 4.36e-1 19/33 (57.58%) BNIP1;STX6;STX3;...
Malaria -1.42 4.28e-1 44/50 (88%) KLRB1;SELE;IL6;...
Aminoacyl-tRNA biosynthesis -1.42 4.64e-1 15/66 (22.73%) GATB;WARS2;SARS2;...
Glycerolipid metabolism -1.43 5.26e-1 44/61 (72.13%) AKR1B1;LIPF;AGK;...
Central carbon metabolism in cancer -1.54 3.84e-1 67/70 (95.71%) TIGAR;SLC7A5;GLS;...
Non-homologous end-joining -1.56 3.91e-1 11/13 (84.62%) POLM;NHEJ1;DNTT;...
Ribosome biogenesis in eukaryotes -1.60 4.19e-1 52/108 (48.15%) RPP30;IMP3;MDN1;...
Primary immunodeficiency -1.69 2.68e-1 33/38 (86.84%) RFX5;AICDA;CD79A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H