Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWUIJE)

Drug Name
Tolmetin Drug Info
Synonyms
Tolectin; Tolmetina; Tolmetine; Tolmetino; Tolmetinum; Tolmetina [DCIT]; MCN 2559; McN-2559; Tolectin (TN); Tolmetin Sodium, Dihydrate; Tolmetine [INN-French]; Tolmetino [INN-Spanish]; Tolmetinum [INN-Latin]; Tolmetin (USAN/INN); Tolmetin [USAN:BAN:INN]; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish]; 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid; 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid; 1-Methyl-5-p-toluoylpyrrole-2-acetic acid; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid; 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
Therapeutic ClassAntiinflammatory Agents
Cross-matching ID
PubChem CID
5509
ChEBI ID
CHEMBL1020
CAS Number
CAS 26171-23-3
TTD Drug ID
D09BHB
ACDINA Drug ID
D00687

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mismatch repair 2.25 0.00e+0 22/23 (95.65%) MSH2;RPA2;RFC4;...
DNA replication 2.15 0.00e+0 34/36 (94.44%) POLE2;RPA2;DNA2;...
Ribosome biogenesis in eukaryotes 2.01 1.93e-3 52/108 (48.15%) RPP38;MPHOSPH10;POP7;...
Nucleotide excision repair 2.01 1.45e-3 40/47 (85.11%) POLE2;RAD23B;RPA2;...
RNA polymerase 1.90 3.48e-3 23/31 (74.19%) POLR2H;POLR2A;POLR2J;...
Retinol metabolism 1.86 5.79e-3 41/68 (60.29%) CYP1A1;ALDH1A2;CYP2A6;...
Proteasome 1.71 3.06e-2 44/46 (95.65%) PSMF1;PSMD11;PSMB10;...
Mineral absorption 1.70 2.90e-2 48/60 (80%) MT1E;MT2A;MT1HL1;...
Homologous recombination 1.65 4.44e-2 35/41 (85.37%) RAD54B;RPA2;MRE11;...
Non-homologous end-joining 1.65 4.06e-2 11/13 (84.62%) DNTT;MRE11;DCLRE1C;...
Cholesterol metabolism -1.72 4.41e-2 44/50 (88%) LRPAP1;PLTP;ABCA1;...
Viral protein interaction with cytokine and cytokine re... -1.72 4.69e-2 84/100 (84%) CXCL6;IL22RA1;ACKR4;...
Aldosterone synthesis and secretion -1.75 3.34e-2 85/98 (86.73%) ATP1B2;PRKD3;NPR1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.76 3.56e-2 62/70 (88.57%) MAPK9;F11R;ATP6V0A1;...
Terpenoid backbone biosynthesis -1.78 3.13e-2 18/22 (81.82%) DHDDS;ACAT1;HMGCS2;...
Rheumatoid arthritis -1.78 3.18e-2 78/93 (83.87%) CXCL6;IL11;IL1B;...
Cortisol synthesis and secretion -1.81 2.55e-2 58/65 (89.23%) ADCY9;ATF4;CYP11A1;...
Sphingolipid metabolism -1.84 2.79e-2 32/49 (65.31%) SMPD2;ARSA;SMPD3;...
Malaria -1.88 1.74e-2 44/50 (88%) KLRK1;THBS1;IL1B;...
TNF signaling pathway -1.90 2.32e-2 103/112 (91.96%) CXCL6;PTGS2;FADD;...
Chagas disease -1.91 2.79e-2 93/102 (91.18%) C1QA;SERPINE1;FADD;...
Steroid biosynthesis -2.14 0.00e+0 19/20 (95%) LSS;TM7SF2;DHCR24;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 3.33uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 3.33uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 3.33uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 3.33uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 3.33uM - 10uM 24H