Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWUOA8)

Drug Name
PSI-6130 Drug Info
Synonyms R-1656; RO-4995855; Hepatitis C virus therapy, Pharmasset/Roche; PSI-6130-DP; PSI-6130-MP; PSI-6130-TP
Cross-matching ID
PubChem CID
6481236
CAS Number
CAS 817204-33-4
TTD Drug ID
D00RFZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.08 0.00e+0 44/46 (95.65%) PSMA3;PSME2;PSMD12;...
Fanconi anemia pathway 1.76 4.07e-2 36/54 (66.67%) CENPX;REV1;REV3L;...
DNA replication 1.73 4.38e-2 34/36 (94.44%) POLE2;PCNA;MCM2;...
Glycosaminoglycan degradation -1.68 4.86e-2 19/19 (100%) ARSB;GALNS;IDS;...
Osteoclast differentiation -1.70 4.24e-2 117/127 (92.13%) LILRB4;TRAF2;TGFB1;...
Lipid and atherosclerosis -1.72 3.72e-2 190/215 (88.37%) IRAK4;HSPA2;NFKB1;...
NOD-like receptor signaling pathway -1.73 3.71e-2 145/181 (80.11%) TRAF2;SHARPIN;CASR;...
Necroptosis -1.74 3.44e-2 113/159 (71.07%) TRAF2;SHARPIN;TRAF5;...
Arachidonic acid metabolism -1.79 2.14e-2 48/61 (78.69%) PLA2G5;GPX2;PLA2G6;...
Rheumatoid arthritis -1.79 2.32e-2 78/93 (83.87%) ITGB2;IL1B;TNFRSF11A;...
ECM-receptor interaction -1.81 2.07e-2 80/88 (90.91%) LAMB3;TNXB;LAMB2;...
Toll-like receptor signaling pathway -1.82 2.15e-2 94/104 (90.38%) IRAK4;NFKB1;IRF5;...
Pentose phosphate pathway -1.82 2.39e-2 25/30 (83.33%) H6PD;TKTL1;ALDOC;...
Nicotine addiction -1.83 2.53e-2 32/40 (80%) GABRP;GABRA2;CACNA1A;...
NF-kappa B signaling pathway -1.85 2.35e-2 90/104 (86.54%) TRAF5;BCL2A1;CCL13;...
Ferroptosis -1.89 1.48e-2 36/41 (87.8%) PCBP2;ATG7;SLC3A2;...
Amoebiasis -1.91 1.52e-2 99/102 (97.06%) LAMB3;PRKACA;NFKB1;...
Neutrophil extracellular trap formation -1.92 1.90e-2 101/189 (53.44%) MAPK3;PRKCA;SIGLEC9;...
Lysosome -1.95 2.53e-2 115/128 (89.84%) AP1G1;M6PR;LIPA;...
TNF signaling pathway -2.01 6.33e-3 103/112 (91.96%) NFKB1;TNFRSF1B;TNFRSF1A;...
IL-17 signaling pathway -2.04 0.00e+0 84/94 (89.36%) RELA;IL17RA;IL17RC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H