Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWUS8N)

Drug Name
Licarbazepine Drug Info
Synonyms
GP 47779; GP-47779; (-)-10,11-Dihydro-10-hydroxy-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-hydroxy-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-hydroxycarbamazepine; 10-HYDROXY-CARBAMAZEPINE; 10-Hydroxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide; 10-Hydroxy-10,11-dihydrocarbamazepine; 10-Hydroxycarbamazepine; 10-Hydroxycarbazepine; 10-OH-Carbazepine; 5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
Cross-matching ID
PubChem CID
114709
ChEBI ID
CHEMBL701
CAS Number
CAS 29331-92-8
TTD Drug ID
D08NLQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.08 0.00e+0 101/150 (67.33%) LSM5;PUF60;SNRPG;...
Ribosome 1.95 9.59e-3 113/158 (71.52%) RPS5;MRPL13;RPS4Y1;...
Nicotinate and nicotinamide metabolism -1.82 1.92e-2 25/35 (71.43%) SIRT7;BST1;CD38;...
Bladder cancer -1.83 2.30e-2 40/41 (97.56%) CCND1;RASSF1;ARAF;...
Type I diabetes mellitus -1.84 2.88e-2 38/43 (88.37%) INS;HLA-F;HLA-DOB;...
Thyroid cancer -1.84 3.84e-2 36/37 (97.3%) PAX8;TPR;RET;...
Primary immunodeficiency -1.86 4.71e-2 33/38 (86.84%) RFXANK;ZAP70;CD3E;...
Basal cell carcinoma -1.96 3.14e-2 41/63 (65.08%) GLI3;FZD4;TP53;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H