Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWX3HT)

• Drug Name: ACEA Drug Info
• Synonyms: Arachidonyl-2-chloroethylamide; arachidonyl-2-chloroethylamide; Arachidonyl-2'-chloroethylamide; CHEMBL151167; (5Z,8Z,11Z,14Z)-N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide; C22H36ClNO; Arachidonoyl-2-chloroethylamide; AC1NSJTE; GTPL738; SCHEMBL1517676; MolPort-003-940-362; HMS3649N11; MFCD02683581; BN0049; BDBM50072769; ZINC13675373; 1595AH; AKOS024456526; Arachidonyl-2'-chloroethylamide hydrate; NCGC00162406-01; LS-63778; ACM273734079; SR-01000946682; L000112; SR-01000946682-1; N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
• Cross-matching ID:
  PubChem CID: 5311006
  ChEBI ID: CHEMBL151167
  CAS Number: CAS 220556-69-4
  TTD Drug ID: D00VCW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
PPAR signaling pathway	-1.75	4.41e-2	66/74 (89.19%)	NR1H3;RXRB;FABP5;...
Bile secretion	-1.79	3.12e-2	68/90 (75.56%)	SLC22A1;HMGCR;PRKACA;...
Staphylococcus aureus infection	-1.86	1.54e-2	72/95 (75.79%)	KRT14;FPR3;C5;...
Steroid hormone biosynthesis	-1.87	1.93e-2	43/61 (70.49%)	HSD11B2;UGT2B4;DHRS11;...
Complement and coagulation cascades	-1.95	1.47e-2	76/85 (89.41%)	KNG1;C9;PLAT;...
Retinol metabolism	-2.02	0.00e+0	41/68 (60.29%)	ADH1A;CYP2C8;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450	-2.44	0.00e+0	49/77 (63.64%)	GSTT1;GSTK1;ADH1A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲