Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWX683)

• Drug Name: Mupirocin Drug Info
• Synonyms: Bactoderm; Bactroban; Centany; MRC; Mupirocina; Mupirocine; Mupirocinum; Plasimine; Bactroban Nasal; Mupirocina [Spanish]; Mupirocine [French]; Mupirocinum [Latin]; Pseudomonic acid; Pseudomonic acid A; BRL 4910A; BRL-4910A; Bactroban (TN); Centany (TN); Mupirocin (USP/INN); Mupirocin, 14C-Labeled; 5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S); 8-Carboxyoctyl (E)-4-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxytetrahydro-2H-pyran-2-yl)-3-methylcrotonat; 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 446596
  ChEBI ID: CHEMBL719
  CAS Number: CAS 12650-69-0
  TTD Drug ID: D03JSJ
  ACDINA Drug ID: D01263

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Retinol metabolism	2.08	1.09e-2	41/68 (60.29%)	DHRS3;CYP2C8;ADH1C;...
Spliceosome	2.03	5.44e-3	101/150 (67.33%)	SRSF1;PUF60;SF3B2;...
Bile secretion	1.96	3.62e-3	68/90 (75.56%)	AQP1;SLC4A4;FXYD2;...
Metabolism of xenobiotics by cytochrome P450	1.92	5.44e-3	49/77 (63.64%)	CYP1B1;GSTT1;ADH1C;...
Vibrio cholerae infection	1.90	6.52e-3	44/50 (88%)	PRKCA;ATP6V0E2;ACTB;...
Histidine metabolism	1.85	1.45e-2	16/22 (72.73%)	MAOB;HNMT;AOC1;...
DNA replication	1.84	2.02e-2	34/36 (94.44%)	MCM5;PRIM2;POLD4;...
Primary bile acid biosynthesis	1.75	3.67e-2	15/17 (88.24%)	AKR1C4;AMACR;BAAT;...
Pentose phosphate pathway	1.72	4.95e-2	25/30 (83.33%)	ALDOB;PFKP;PFKL;...
Proximal tubule bicarbonate reclamation	1.71	4.68e-2	21/23 (91.3%)	AQP1;SLC4A4;GLUD2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼