Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWX8UM)

Drug Name
Trehalose Drug Info
Synonyms
trehalose; D-Trehalose; 99-20-7; alpha,alpha-trehalose; Mycose; Ergot sugar; alpha-D-Trehalose; D-(+)-Trehalose; alpha,alpha'-Trehalose; Trehaose; Treha; alpha-Trehalose; UNII-B8WCK70T7I; alpha-D-glucopyranosyl-alpha-D-glucopyranoside; D(+)-Trehalose; D-(+)-Trehalose, anhydrous; Natural trehalose; TREHALOSE, DIHYDRATE; alpha,alpha'-D-Trehalose; alpha-D-Glucopyranoside, alpha-D-glucopyranosyl; B8WCK70T7I; CHEBI:16551; alpha-D-glucopyranosyl alpha-D-glucopyranoside; Neotrehalose; Thealoz; NSC 2093; TRE; Trehalose, alpha,alpha'-; Trehalo
Cross-matching ID
PubChem CID
7427
ChEBI ID
CHEMBL16551
CAS Number
CAS 99-20-7
TTD Drug ID
D0VC8Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.92 2.68e-2 34/36 (94.44%) MCM7;PCNA;POLE2;...
Phenylalanine metabolism -1.62 4.51e-2 14/17 (82.35%) ALDH3A1;PAH;ALDH3B1;...
Leukocyte transendothelial migration -1.62 4.65e-2 90/114 (78.95%) MYL5;CLDN4;MYL7;...
Aldosterone-regulated sodium reabsorption -1.63 4.30e-2 34/37 (91.89%) KCNJ1;ATP1A2;MAPK1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.64 4.41e-2 62/70 (88.57%) CXCL3;EGFR;CXCL1;...
Mucin type O-glycan biosynthesis -1.64 4.44e-2 20/36 (55.56%) GALNT7;GALNT6;GALNT3;...
Lysosome -1.64 4.52e-2 115/128 (89.84%) AP3S1;HGSNAT;PLA2G15;...
Natural killer cell mediated cytotoxicity -1.65 4.14e-2 99/131 (75.57%) BRAF;LCK;ITGB2;...
Dopaminergic synapse -1.66 4.05e-2 115/132 (87.12%) ITPR1;TH;GNAI1;...
IL-17 signaling pathway -1.67 3.83e-2 84/94 (89.36%) MAPK10;MAPK11;IL17RA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.68 3.84e-2 79/89 (88.76%) MAPK11;PPP3CA;JAK2;...
Starch and sucrose metabolism -1.68 3.85e-2 25/36 (69.44%) GYS1;GBA3;PYGB;...
Salivary secretion -1.68 3.79e-2 76/93 (81.72%) ATP1B3;LPO;HTN3;...
Proximal tubule bicarbonate reclamation -1.69 3.65e-2 21/23 (91.3%) ATP1B3;SLC4A4;GLUD2;...
Necroptosis -1.69 3.72e-2 113/159 (71.07%) SMPD1;IL1B;EIF2AK2;...
Insulin secretion -1.69 3.80e-2 75/86 (87.21%) ADCY8;GCG;CREB3L1;...
Renin-angiotensin system -1.70 3.80e-2 20/23 (86.96%) PRCP;AGTR2;PREP;...
Osteoclast differentiation -1.71 3.72e-2 117/127 (92.13%) LILRA4;IL1B;MAP3K7;...
Serotonergic synapse -1.71 3.82e-2 97/114 (85.09%) HTR2A;ITPR1;GNAI1;...
Pentose phosphate pathway -1.71 3.83e-2 25/30 (83.33%) ALDOC;RPIA;RBKS;...
C-type lectin receptor signaling pathway -1.71 3.95e-2 93/104 (89.42%) CYLD;ITPR1;CASP1;...
Kaposi sarcoma-associated herpesvirus infection -1.76 2.61e-2 172/193 (89.12%) MAPK10;MAPK11;IFNAR1;...
Leishmaniasis -1.78 2.48e-2 67/77 (87.01%) MAPK11;HLA-DOB;JAK2;...
Fc epsilon RI signaling pathway -1.79 2.17e-2 57/68 (83.82%) PLA2G4C;MAPK10;MAPK11;...
Neutrophil extracellular trap formation -1.80 2.30e-2 101/189 (53.44%) ITGB2;SELPLG;HAT1;...
Tyrosine metabolism -1.83 1.45e-2 30/36 (83.33%) GOT2;HGD;TPO;...
Steroid biosynthesis -1.85 1.24e-2 19/20 (95%) NSDHL;SOAT1;CYP2R1;...
Adrenergic signaling in cardiomyocytes -1.86 1.24e-2 130/150 (86.67%) ADCY8;GNAI1;PPP1CB;...
Carbohydrate digestion and absorption -1.88 8.27e-3 37/47 (78.72%) ATP1A2;CACNA1D;ATP1B2;...
Cardiac muscle contraction -1.92 6.20e-3 64/87 (73.56%) TPM2;ATP1B3;SLC9A1;...
Gastric acid secretion -1.97 0.00e+0 63/76 (82.89%) ATP1B3;ITPR1;ADCY8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H