Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWY0TN)

• Drug Name: LICOAGROCHACONE A Drug Info
• Synonyms: licochalcone a; 58749-22-7; Licochalcone-A; UNII-JTV5467968; 3-Dimethylallyl-4,4'-dihydroxy-6-methoxychalcone; CHEMBL139702; C21H22O4; JTV5467968; (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one; Licochalcone-A, Synthetic; Q-100677; (E)-3-[5-(1,1-dimethylallyl)-4-hydroxy-2-methoxy-phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (E)-
• Cross-matching ID:
  PubChem CID: 5318998
  ChEBI ID: CHEMBL139702
  CAS Number: CAS 58749-22-7
  TTD Drug ID: D08GEN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.37	0.00e+0	93/133 (69.92%)	ATP6V1C1;NDUFB5;ATP6V1D;...
Ribosome	2.17	0.00e+0	113/158 (71.52%)	MRPS16;RPS4Y1;RPL13;...
Mineral absorption	2.07	0.00e+0	48/60 (80%)	HMOX1;STEAP1;ATP2B1;...
Epithelial cell signaling in Helicobacter pylori infect...	1.97	2.45e-3	62/70 (88.57%)	CXCL8;ATP6V1C1;MAPK13;...
Nitrogen metabolism	1.96	1.96e-3	16/17 (94.12%)	CA2;GLUL;CA4;...
Folate biosynthesis	1.96	1.63e-3	23/26 (88.46%)	AKR1C3;AKR1B10;GCH1;...
Collecting duct acid secretion	1.96	1.40e-3	22/27 (81.48%)	CA2;ATP6V1C1;ATP6V1D;...
Thiamine metabolism	1.85	6.12e-3	12/15 (80%)	AK4;TPK1;AK5;...
Citrate cycle (TCA cycle)	1.85	5.44e-3	30/30 (100%)	DLD;ACLY;PCK1;...
Mismatch repair	1.83	6.86e-3	22/23 (95.65%)	PCNA;RPA3;RPA2;...
IL-17 signaling pathway	1.81	1.07e-2	84/94 (89.36%)	CXCL8;CXCL5;S100A7;...
SNARE interactions in vesicular transport	1.77	1.47e-2	19/33 (57.58%)	BET1;STX3;SNAP29;...
Amyotrophic lateral sclerosis	1.72	3.09e-2	267/364 (73.35%)	GRIA2;MAPK13;DAXX;...
Proximal tubule bicarbonate reclamation	1.71	3.22e-2	21/23 (91.3%)	CA2;SLC4A4;PCK1;...
DNA replication	1.67	3.92e-2	34/36 (94.44%)	PCNA;RPA3;MCM6;...
Parkinson disease	1.66	3.92e-2	176/249 (70.68%)	PPIF;CALML4;DAXX;...
Non-alcoholic fatty liver disease	1.66	3.74e-2	126/155 (81.29%)	CXCL8;MAPK13;CASP7;...
Rheumatoid arthritis	1.66	3.54e-2	78/93 (83.87%)	CXCL8;CXCL5;ATP6V1C1;...
TNF signaling pathway	1.66	3.71e-2	103/112 (91.96%)	CXCL5;MAPK13;CASP7;...
Diabetic cardiomyopathy	1.65	3.87e-2	162/203 (79.8%)	GAPDH;PPIF;CYBA;...
Thermogenesis	1.64	4.06e-2	173/232 (74.57%)	KDM3A;MAPK13;CPT1A;...
Legionellosis	1.64	3.96e-2	51/57 (89.47%)	CXCL8;EEF1A2;CASP7;...
Phosphonate and phosphinate metabolism	1.63	4.43e-2	5/6 (83.33%)	CHPT1;CEPT1
Primary immunodeficiency	-2.09	0.00e+0	33/38 (86.84%)	CD19;CD3E;AICDA;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼