Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMWZ2TU)

Drug Name
CO-1686 Drug Info
Synonyms
1374640-70-6; AVL-301; CO1686; UNII-72AH61702G; CNX-419; CO-1686 (AVL-301); Rociletinib(AVL-301,CNX-419,CO-1686); 72AH61702G; N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; CO 1686; Rociletinib (CO-1686, AVL-301); Rociletinib [USAN:INN]; Tube721; Rociletinib (USAN/INN); Rociletinib (CO-1686); SCHEMBL4177736; GTPL7966; CHEMBL3545308; EX-A228; MolPort-035-395-816; C27H28F3N7O3; HMS3653G08; BDBM149404; BCP07085; AOB87314; ZINC98043800; s7284
Cross-matching ID
PubChem CID
57335384
ChEBI ID
CHEMBL3545308
CAS Number
CAS 1374640-70-6
TTD Drug ID
D0M4AV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proximal tubule bicarbonate reclamation 2.35 0.00e+0 21/23 (91.3%) ATP1A2;PCK1;CA2;...
Retinol metabolism 2.23 0.00e+0 41/68 (60.29%) ADH1B;ADH1C;UGT2B15;...
Tyrosine metabolism 2.19 0.00e+0 30/36 (83.33%) ADH1B;ADH1C;HPD;...
Steroid hormone biosynthesis 1.99 2.20e-3 43/61 (70.49%) HSD17B2;UGT2B15;HSD11B1;...
Phenylalanine metabolism 1.98 1.76e-3 14/17 (82.35%) HPD;GLYAT;PAH;...
Metabolism of xenobiotics by cytochrome P450 1.94 1.47e-3 49/77 (63.64%) ADH1B;ADH1C;UGT2B15;...
Drug metabolism 1.90 1.26e-3 78/151 (51.66%) ADH1B;ADH1C;UGT2B15;...
Complement and coagulation cascades 1.85 6.61e-3 76/85 (89.41%) C1S;C1R;C7;...
Fatty acid degradation 1.84 6.85e-3 40/43 (93.02%) ADH1B;ACAA2;ADH1C;...
Glyoxylate and dicarboxylate metabolism 1.80 1.41e-2 23/30 (76.67%) ACAT1;ACAT2;GLUL;...
Pentose and glucuronate interconversions 1.78 1.60e-2 17/34 (50%) AKR1B10;UGT2B15;UGT2B17;...
Tryptophan metabolism 1.78 1.54e-2 35/42 (83.33%) ACAT1;ACAT2;AOC1;...
p53 signaling pathway 1.78 1.63e-2 63/73 (86.3%) CHEK1;CDK1;THBS1;...
MicroRNAs in cancer 1.77 1.64e-2 146/310 (47.1%) CDC25B;MMP9;PDGFRA;...
Arginine biosynthesis 1.73 2.17e-2 17/22 (77.27%) ASS1;GLUL;GLS2;...
Valine, leucine and isoleucine degradation 1.72 2.31e-2 42/48 (87.5%) ACAA2;ACAT1;MCCC2;...
Nicotinate and nicotinamide metabolism 1.72 2.23e-2 25/35 (71.43%) ENPP1;NT5C2;NNMT;...
One carbon pool by folate 1.71 2.25e-2 15/20 (75%) MTHFD1;DHFR;ATIC;...
Aldosterone-regulated sodium reabsorption 1.70 2.18e-2 34/37 (91.89%) SGK1;INSR;ATP1A2;...
Primary immunodeficiency 1.65 3.57e-2 33/38 (86.84%) CD79A;RFX5;PTPRC;...
Ribosome biogenesis in eukaryotes -1.96 3.55e-2 52/108 (48.15%) DKC1;NAT10;NVL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 12.5uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H