Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX0K3Q)

• Drug Name: Epinastine Drug Info
• Synonyms: Epinastina; Epinastinum; Purivist; Epinastina [Spanish]; Epinastine [INN]; Epinastinum [Latin]; WAL 80; WAL 801; WAL 801CL; Elestat (TN); Epinastine (INN); Purivist (TN); Relestat (TN); WAL-80 Cl; (+-)-Epinastine; 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine; 3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine; 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
• Therapeutic Class: Antihistamines
• Cross-matching ID:
  PubChem CID: 3241
  ChEBI ID: CHEMBL1106
  CAS Number: CAS 80012-43-7
  TTD Drug ID: D0DV3O
  VARIDT Drug ID: DR01010
  INTEDE Drug ID: DR0587

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.20	0.00e+0	48/60 (80%)	MT1F;MT1HL1;MT1G;...
Butanoate metabolism	1.97	0.00e+0	23/28 (82.14%)	ACAT2;HMGCS2;EHHADH;...
Terpenoid backbone biosynthesis	1.96	0.00e+0	18/22 (81.82%)	ACAT2;HMGCS2;HMGCS1;...
Metabolism of xenobiotics by cytochrome P450	1.91	2.73e-3	49/77 (63.64%)	HSD11B1;AKR7A2;GSTO1;...
Synthesis and degradation of ketone bodies	1.89	2.18e-3	9/10 (90%)	ACAT2;HMGCS2;HMGCS1;...
Nitrogen metabolism	1.86	1.09e-2	16/17 (94.12%)	CA2;GLUL;CA9;...
Proteasome	1.85	9.34e-3	44/46 (95.65%)	PSMA2;PSMB3;PSMD4;...
Primary immunodeficiency	1.85	9.54e-3	33/38 (86.84%)	CD40;IL7R;CD3D;...
Peroxisome	1.82	1.57e-2	72/82 (87.8%)	EHHADH;SCP2;PECR;...
Nucleotide excision repair	1.77	2.18e-2	40/47 (85.11%)	RAD23B;POLE2;RFC5;...
Drug metabolism	1.73	3.07e-2	78/151 (51.66%)	GSTO1;CYP3A4;GSTT1;...
Mismatch repair	1.72	2.82e-2	22/23 (95.65%)	RFC5;POLD2;EXO1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H	Show ▼