Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX1AY4)

Drug Name
PD-168077 Drug Info
Synonyms
PD-168077; 190383-31-4; CHEMBL45244; PD 168077; PD-168,077; N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide; Benzamide, N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-; PD 168,077 maleate salt; N-((4-(2-cyanophenyl)piperazin-1-yl)methyl)-3-methylbenzamide; AC1MURTZ; Tocris-1065; NCGC00015791-01; Lopac-P-233; Biomol-NT_000050; Lopac0_000969; GTPL975; BPBio1_001301; SCHEMBL4002275; DTXSID7044007; NOCAS_44007; CHEBI:94634; BCP08352; ZINC25758996; BDBM50058225; AKOS028108749; CCG-205049; NCGC00024977-02
Cross-matching ID
PubChem CID
3645619
ChEBI ID
CHEMBL45244
CAS Number
CAS 190383-31-4
TTD Drug ID
D0G8VU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arginine and proline metabolism -1.78 4.87e-2 39/50 (78%) MAOB;AMD1;PYCR1;...
Bile secretion -1.82 3.82e-2 68/90 (75.56%) ABCB1;SLC5A1;ABCC2;...
Pentose and glucuronate interconversions -1.89 4.58e-2 17/34 (50%) XYLB;GUSB;AKR1B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H