Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX38HQ)

Drug Name
Apomorphine Drug Info
Synonyms Apomorphine (intranasal, Parkinson's disease)
Cross-matching ID
PubChem CID
6005
ChEBI ID
CHEMBL53
CAS Number
CAS 58-00-4
TTD Drug ID
D0H6QU
VARIDT Drug ID
DR00890
INTEDE Drug ID
DR0123

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.05 1.07e-2 103/112 (91.96%) CXCL2;CCL20;CXCL3;...
Inflammatory bowel disease 2.04 5.34e-3 58/65 (89.23%) TLR4;IL2RG;RORA;...
Tryptophan metabolism 2.03 3.56e-3 35/42 (83.33%) KYNU;TDO2;CYP1B1;...
NF-kappa B signaling pathway 1.98 2.67e-3 90/104 (86.54%) CXCL2;CXCL8;TLR4;...
Rheumatoid arthritis 1.98 2.13e-3 78/93 (83.87%) CXCL2;CCL20;CXCL8;...
Steroid biosynthesis 1.97 1.78e-3 19/20 (95%) SC5D;DHCR7;NSDHL;...
Mitophagy 1.92 3.05e-3 56/68 (82.35%) SRC;OPTN;TBC1D15;...
NOD-like receptor signaling pathway 1.91 2.67e-3 145/181 (80.11%) CXCL2;CXCL8;TLR4;...
IL-17 signaling pathway 1.85 8.30e-3 84/94 (89.36%) CXCL2;S100A7;CCL20;...
Th17 cell differentiation 1.84 7.47e-3 95/107 (88.79%) IL2RG;CD3D;STAT5A;...
Glyoxylate and dicarboxylate metabolism 1.84 6.79e-3 23/30 (76.67%) GLUL;MMUT;ACAT1;...
Pantothenate and CoA biosynthesis 1.83 6.23e-3 14/21 (66.67%) DPYD;ALDH2;ALDH3A2;...
Propanoate metabolism 1.82 9.85e-3 30/34 (88.24%) MMUT;ALDH6A1;ACAT1;...
Pentose phosphate pathway 1.81 9.15e-3 25/30 (83.33%) PFKL;PGD;RBKS;...
Influenza A 1.77 1.64e-2 156/172 (90.7%) CXCL8;TLR4;OAS2;...
Protein export 1.74 2.20e-2 17/23 (73.91%) SRP54;SRP72;SRPRB;...
Th1 and Th2 cell differentiation 1.74 2.13e-2 80/92 (86.96%) IL2RG;CD3D;STAT5A;...
PD-L1 expression and PD-1 checkpoint pathway in cancer 1.73 2.08e-2 79/89 (88.76%) TLR4;CD3D;CD3E;...
Histidine metabolism 1.71 2.47e-2 16/22 (72.73%) ALDH2;ALDH3A2;ALDH3A1;...
beta-Alanine metabolism 1.70 2.35e-2 25/30 (83.33%) DPYD;ALDH2;ALDH3A2;...
Chemokine signaling pathway 1.70 2.29e-2 163/192 (84.9%) CXCL2;CCL20;CXCL8;...
Measles 1.69 2.38e-2 133/139 (95.68%) TLR4;OAS2;IL2RG;...
RIG-I-like receptor signaling pathway 1.69 2.37e-2 64/70 (91.43%) CXCL8;IFIH1;CXCL10;...
Graft-versus-host disease 1.69 2.27e-2 32/42 (76.19%) HLA-DQB1;TNF;IL1B;...
Epithelial cell signaling in Helicobacter pylori infect... 1.69 2.18e-2 62/70 (88.57%) CXCL2;CXCL8;CXCL3;...
Salmonella infection 1.67 2.46e-2 198/249 (79.52%) CXCL8;TLR4;LEF1;...
Valine, leucine and isoleucine degradation 1.66 2.53e-2 42/48 (87.5%) ALDH2;ALDH3A2;MMUT;...
Viral protein interaction with cytokine and cytokine re... 1.65 2.63e-2 84/100 (84%) CXCL2;CCL20;CXCL8;...
Yersinia infection 1.65 2.58e-2 120/137 (87.59%) CXCL8;TLR4;FYB1;...
T cell receptor signaling pathway 1.65 2.53e-2 93/104 (89.42%) CDC42;LCP2;CD3D;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H