Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX4DQH)

Drug Name
Delanzomib Drug Info
Synonyms
((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutan-2-yl)boronic acid; s1157; ZINC202536926; SB16695; SW219161-1; boronic acid, b-[(1r)-1-[[(2s,3r)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]-
Cross-matching ID
PubChem CID
24800541
ChEBI ID
CHEMBL270515
CAS Number
CAS 847499-27-8
TTD Drug ID
D0VO0T

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.68 0.00e+0 44/46 (95.65%) PSMD11;PSMD12;PSMC2;...
Protein processing in endoplasmic reticulum 2.35 0.00e+0 127/171 (74.27%) HSPA1A;HSPA6;HSPH1;...
Spinocerebellar ataxia 2.24 0.00e+0 128/143 (89.51%) PSMD11;PSMD12;PSMC2;...
Parkinson disease 2.07 0.00e+0 176/249 (70.68%) UCHL1;PSMD11;PSMD12;...
Amyotrophic lateral sclerosis 1.99 1.88e-3 267/364 (73.35%) SQSTM1;GABARAPL1;PSMD11;...
Collecting duct acid secretion 1.97 1.57e-3 22/27 (81.48%) ATP6V0E1;ATP6V1A;CA2;...
Salmonella infection 1.92 1.34e-3 198/249 (79.52%) TUBB2A;MYC;RAB9A;...
Alzheimer disease 1.88 3.52e-3 279/369 (75.61%) PSMD11;PSMD12;PSMC2;...
Prion disease 1.84 4.18e-3 209/273 (76.56%) HSPA1A;HSPA6;PSMD11;...
Pathways of neurodegeneration 1.83 6.58e-3 354/475 (74.53%) UCHL1;SQSTM1;GABARAPL1;...
Mitophagy 1.79 1.28e-2 56/68 (82.35%) SQSTM1;GABARAPL1;JUN;...
Epithelial cell signaling in Helicobacter pylori infect... 1.77 1.49e-2 62/70 (88.57%) CCL5;ATP6V0E1;JUN;...
Ribosome biogenesis in eukaryotes 1.76 1.59e-2 52/108 (48.15%) CSNK2A1;REXO2;RPP40;...
Huntington disease 1.73 2.08e-2 233/306 (76.14%) PSMD11;PSMD12;PSMC2;...
Folate biosynthesis 1.72 2.07e-2 23/26 (88.46%) AKR1C3;AKR1B10;FPGS;...
Protein export 1.71 2.58e-2 17/23 (73.91%) SRP54;SEC61A2;SRPRA;...
TNF signaling pathway 1.66 3.87e-2 103/112 (91.96%) CCL5;EDN1;JAG1;...
Ferroptosis 1.65 3.65e-2 36/41 (87.8%) SLC7A11;GCLM;MAP1LC3B;...
Legionellosis 1.64 3.91e-2 51/57 (89.47%) HSPA1A;HSPA6;SAR1B;...
Endocytosis 1.64 3.95e-2 198/252 (78.57%) DNM1;HSPA1A;HSPA6;...
Epstein-Barr virus infection 1.62 4.43e-2 189/202 (93.56%) PSMD11;PSMD12;PSMC2;...
Toxoplasmosis 1.61 4.70e-2 103/112 (91.96%) HSPA1A;HSPA6;LAMB3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 0.125uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H