Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX4VY9)

Drug Name
isobutyric acid Drug Info
Synonyms isobutyrate
Cross-matching ID
PubChem CID
6590
ChEBI ID
CHEMBL16135
CAS Number
CAS 79-31-2
TTD Drug ID
D06ZVB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fructose and mannose metabolism 2.02 0.00e+0 30/33 (90.91%) PFKL;PFKP;SORD;...
Glycolysis / Gluconeogenesis 1.97 5.13e-3 56/67 (83.58%) DLD;PFKL;PFKP;...
Rheumatoid arthritis 1.95 6.85e-3 78/93 (83.87%) HLA-DQA1;ATP6V1D;ACP5;...
Epithelial cell signaling in Helicobacter pylori infect... 1.83 1.80e-2 62/70 (88.57%) ATP6V1D;CXCL3;HBEGF;...
Non-homologous end-joining 1.82 1.64e-2 11/13 (84.62%) DNTT;DCLRE1C;POLL;...
Galactose metabolism 1.76 3.08e-2 26/31 (83.87%) PFKL;PFKP;MGAM;...
Lysine degradation 1.75 2.93e-2 51/63 (80.95%) DLD;PLOD2;BBOX1;...
Pentose phosphate pathway 1.73 3.59e-2 25/30 (83.33%) PFKL;PFKP;ALDOB;...
Mismatch repair 1.71 4.11e-2 22/23 (95.65%) PCNA;MSH2;SSBP1
Citrate cycle (TCA cycle) 1.70 4.00e-2 30/30 (100%) DLD;PCK1;IDH3B;...
Tryptophan metabolism 1.69 4.20e-2 35/42 (83.33%) DLD;AOC1;ECHS1;...
Glutamatergic synapse -1.94 1.46e-2 97/114 (85.09%) GLS2;GRIA3;CACNA1A;...
Salivary secretion -1.97 9.74e-3 76/93 (81.72%) HTN3;ATP1A1;PRB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H