Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX6UYN)

Drug Name
(+)-BUTACLAMOL Drug Info
Synonyms
d-Butaclamol; (+)-Butaclamol; BUTACLAMOL; CHEMBL8514; 56245-67-1; 1H-Benzo(6,7)cyclohepta(1,2,3-de)pyrido(2,1-a)isoquinolin-3-ol, 2,3,4,4a,8,9,13b,14-octahydro-3-(1,1-dimethylethyl)-, (3S-(3-alpha,4a-alpha,13b-beta))-; (+/-)-Butaclamol hydrochloride; BUTACLAMOL,d-; AC1L1XRQ; BUTACLAMOL,(+); GTPL62; BUTACLAMOL, (-); Biomol-NT_000018; Lopac0_000475; Lopac0_000187; SCHEMBL122821; BPBio1_001177; ZZJYIKPMDIWRSN-HWBMXIPRSA-N; CHEBI:109533; HMS2089C08; ZINC2008410; PDSP2_000547; PDSP2_001512; BDBM50008735; CCG-204282; NCGC00162085-04
Cross-matching ID
PubChem CID
37459
ChEBI ID
CHEMBL8514
CAS Number
CAS 56245-67-1
TTD Drug ID
D0O7DA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.12 0.00e+0 113/158 (71.52%) RPS5;RPL36;RPL14;...
Parkinson disease 1.96 5.71e-3 176/249 (70.68%) TUBB2A;TXN;PPIF;...
Folate biosynthesis 1.94 7.61e-3 23/26 (88.46%) AKR1C3;PAH;AKR1B1;...
Oxidative phosphorylation 1.90 2.57e-2 93/133 (69.92%) ATP5MG;ATP5MC2;NDUFB4;...
Drug metabolism 1.88 2.51e-2 78/151 (51.66%) UGT2A3;UPP1;ADH1B;...
Huntington disease 1.79 4.38e-2 233/306 (76.14%) TUBB2A;GPX3;PPIF;...
Tryptophan metabolism 1.78 3.75e-2 35/42 (83.33%) ALDH8A1;AOX1;EHHADH;...
Prion disease 1.76 4.99e-2 209/273 (76.56%) TUBB2A;IL1B;PPIF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H