Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX7A5V)

Drug Name
Faropenem Drug Info
Synonyms
FPM; Fropenem; (+)-(5R,6S)-6-((1R)-1-Hydroxyethyl)-7-oxo-3-((2R)-tetrahydro-2-furyl)-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid; (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; 6alpha-[(1R)-1-hydroxyethyl]-2-[(2R)-tetrahydrofuran-2-yl]-2,3-didehydropenam-3-carboxylic acid
Therapeutic ClassRespiratory Agents
Cross-matching ID
PubChem CID
65894
ChEBI ID
CHEMBL51257
CAS Number
CAS 106560-14-9
TTD Drug ID
D02IIW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.96 7.75e-3 34/36 (94.44%) PRIM1;MCM4;POLA2;...
Proteasome 1.93 3.88e-3 44/46 (95.65%) ADRM1;PSMA3;PSMA7;...
Aminoacyl-tRNA biosynthesis 1.87 7.75e-3 15/66 (22.73%) QRSL1;GATC;NARS2;...
Pyrimidine metabolism 1.84 1.55e-2 40/56 (71.43%) DPYS;ENPP1;CANT1;...
Fanconi anemia pathway 1.83 1.40e-2 36/54 (66.67%) RAD51C;REV1;FAAP100;...
Mineral absorption 1.81 1.42e-2 48/60 (80%) MT1E;MT1HL1;MT1F;...
Homologous recombination 1.77 2.44e-2 35/41 (85.37%) RAD54B;RBBP8;RAD51C;...
Renal cell carcinoma 1.73 3.68e-2 68/69 (98.55%) ARNT2;PAK1;VEGFA;...
Mucin type O-glycan biosynthesis -1.70 4.10e-2 20/36 (55.56%) GALNT2;ST6GALNAC2;ST6GALNAC4;...
Hematopoietic cell lineage -1.73 3.17e-2 90/99 (90.91%) CD1E;TNF;CSF1R;...
Arachidonic acid metabolism -1.79 2.29e-2 48/61 (78.69%) PLA2G2D;PTGDS;PLA2G6;...
Pertussis -1.79 2.49e-2 64/76 (84.21%) ITGB2;NLRP3;IRF3;...
Primary immunodeficiency -1.82 2.00e-2 33/38 (86.84%) PTPRC;RAG1;ADA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.85 1.66e-2 79/89 (88.76%) MAP2K3;MAPK14;PPP3CB;...
Retinol metabolism -1.90 1.09e-2 41/68 (60.29%) RDH16;RDH5;DHRS9;...
Adipocytokine signaling pathway -1.92 8.91e-3 64/69 (92.75%) PTPN11;ACSBG2;PRKAG1;...
Neutrophil extracellular trap formation -1.93 1.04e-2 101/189 (53.44%) MAPK14;FPR2;PLCB1;...
Steroid hormone biosynthesis -1.98 9.98e-3 43/61 (70.49%) AKR1C4;CYP3A4;CYP1A1;...
Histidine metabolism -1.99 1.25e-2 16/22 (72.73%) HDC;ALDH3A2;MAOA;...
Th1 and Th2 cell differentiation -2.01 1.66e-2 80/92 (86.96%) IL13;MAPK14;PPP3CB;...
NF-kappa B signaling pathway -2.03 2.49e-2 90/104 (86.54%) CSNK2A2;CD40;TRAF6;...
Metabolism of xenobiotics by cytochrome P450 -2.20 0.00e+0 49/77 (63.64%) CYP3A4;HPGDS;ADH7;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H