Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX7BM4)

Drug Name
Efaproxyn Drug Info
Synonyms Efaproxiral; RSR13
Cross-matching ID
PubChem CID
122335
CAS Number
CAS 131179-95-8
TTD Drug ID
D03HVV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.39 0.00e+0 34/36 (94.44%) MCM3;POLE2;MCM5;...
Ribosome biogenesis in eukaryotes 2.09 0.00e+0 52/108 (48.15%) IMP4;PWP2;DKC1;...
Homologous recombination 2.03 3.08e-3 35/41 (85.37%) RPA3;RAD54L;RBBP8;...
ECM-receptor interaction 1.94 1.16e-2 80/88 (90.91%) SPP1;COL1A2;LAMA3;...
Leishmaniasis 1.92 9.25e-3 67/77 (87.01%) TLR4;HLA-DQB1;FCGR2C;...
Systemic lupus erythematosus 1.89 9.25e-3 45/135 (33.33%) CD40;HLA-DQB1;FCGR3B;...
Asthma 1.86 1.19e-2 25/31 (80.65%) CD40;HLA-DQB1;TNF;...
Toll-like receptor signaling pathway 1.86 1.04e-2 94/104 (90.38%) SPP1;TLR4;CD40;...
Cell cycle 1.85 9.25e-3 110/124 (88.71%) MCM3;ORC1;MCM5;...
Malaria 1.83 1.11e-2 44/50 (88%) TLR4;CD40;TLR2;...
Pyrimidine metabolism 1.74 1.85e-2 40/56 (71.43%) RRM2;NME1;DTYMK;...
Neutrophil extracellular trap formation 1.71 2.70e-2 101/189 (53.44%) TLR4;FCGR3B;CYBB;...
Intestinal immune network for IgA production 1.71 2.63e-2 38/48 (79.17%) CD40;HLA-DQB1;TGFB1;...
Focal adhesion 1.70 2.51e-2 180/201 (89.55%) SPP1;COL1A2;LAMA3;...
Fanconi anemia pathway 1.67 3.64e-2 36/54 (66.67%) RPA3;CENPX;FANCA;...
Primary immunodeficiency 1.66 3.82e-2 33/38 (86.84%) CD40;BLNK;AICDA;...
One carbon pool by folate 1.66 3.70e-2 15/20 (75%) MTHFD1;GART;MTHFD2L;...
Allograft rejection 1.63 4.37e-2 32/38 (84.21%) CD40;HLA-DQB1;GZMB;...
Parkinson disease -1.70 4.49e-2 176/249 (70.68%) NDUFB11;PRKACB;CALML4;...
Synaptic vesicle cycle -1.71 4.08e-2 63/78 (80.77%) DNM2;RAB3A;ATP6V1F;...
Renin secretion -1.73 3.22e-2 61/69 (88.41%) GUCY1A1;PRKACB;CALML4;...
Vibrio cholerae infection -1.75 2.95e-2 44/50 (88%) TCIRG1;ATP6V0A1;ATP6V1A;...
Tryptophan metabolism -1.76 2.91e-2 35/42 (83.33%) ALDH2;ALDH8A1;CYP1A1;...
Other glycan degradation -1.79 2.68e-2 13/18 (72.22%) GLB1;MAN2B1;MAN2B2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.81 2.36e-2 62/70 (88.57%) ATP6V1F;CCL5;MET;...
Oxidative phosphorylation -1.95 8.05e-3 93/133 (69.92%) NDUFS4;TCIRG1;ATP6V0A1;...
Steroid biosynthesis -1.96 7.16e-3 19/20 (95%) EBP;FDFT1;DHCR24;...
Sphingolipid metabolism -2.00 1.07e-2 32/49 (65.31%) SMPD3;SPTLC1;SPTLC2;...
Lysosome -2.12 0.00e+0 115/128 (89.84%) CD63;CTSL;CTSV;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H