Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX8BS5)

Drug Name
ELLAGIC ACID Drug Info
Synonyms
ellagic acid; 476-66-4; Benzoaric acid; Lagistase; Eleagic acid; Alizarine Yellow; Elagostasine; 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione; Ellagic acid dihydrate; Llagic acid; Acide ellagique; Acido elagico; Acidum ellagicum; C.I. 55005; Gallogen (VAN); Gallogen (astringent); C.I. 75270; Ellagate; Ellagic acid [INN:DCF]; UNII-19YRN3ZS9P; Acido elagico [INN-Spanish]; CCRIS 774; Gallogen, astringent; Acide ellagique [INN-French]; Acidum ellagicum [INN-Latin]; MLS000069632; C14H6O8; EINECS 207-508-3; NSC407286; NSC 40728
Cross-matching ID
PubChem CID
5281855
ChEBI ID
CHEMBL6246
CAS Number
CAS 476-66-4
TTD Drug ID
D0A1CM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.42 0.00e+0 101/150 (67.33%) HSPA8;SRSF7;PRPF4;...
Proteasome 2.41 0.00e+0 44/46 (95.65%) PSMD14;PSMD1;PSMD11;...
Ribosome biogenesis in eukaryotes 2.39 0.00e+0 52/108 (48.15%) NVL;POP5;NOP56;...
RNA transport 2.02 3.64e-3 128/186 (68.82%) POP5;NCBP1;GEMIN6;...
Ribosome 1.97 4.37e-3 113/158 (71.52%) RPL26L1;MRPS16;MRPL19;...
Basal transcription factors 1.96 3.64e-3 37/45 (82.22%) GTF2H5;TAF15;GTF2H4;...
Oocyte meiosis 1.79 1.98e-2 90/129 (69.77%) CDC20;PLK1;CCNB2;...
DNA replication 1.75 2.46e-2 34/36 (94.44%) FEN1;POLE2;PCNA;...
Aminoacyl-tRNA biosynthesis 1.71 3.23e-2 15/66 (22.73%) IARS2;DARS2;LARS2;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.69 3.71e-2 9/11 (81.82%) NQO1;HPD;COQ3;...
Homologous recombination 1.67 4.10e-2 35/41 (85.37%) BRCA1;BRIP1;BLM;...
Parkinson disease 1.66 3.94e-2 176/249 (70.68%) MAOB;HSPA5;PSMD14;...
RNA polymerase 1.63 4.76e-2 23/31 (74.19%) POLR3K;POLR3B;POLR3G;...
Spinocerebellar ataxia 1.62 4.42e-2 128/143 (89.51%) PSMD14;NOP56;PSMD1;...
Amyotrophic lateral sclerosis 1.62 4.32e-2 267/364 (73.35%) HSPA5;SRSF7;PSMD14;...
D-Glutamine and D-glutamate metabolism -1.65 3.56e-2 5/5 (100%) GLS;GLUD1;GLUD2
Kaposi sarcoma-associated herpesvirus infection -1.65 3.60e-2 172/193 (89.12%) STAT2;IFNAR2;STAT3;...
Autoimmune thyroid disease -1.67 3.11e-2 46/53 (86.79%) HLA-C;HLA-E;HLA-G;...
HIF-1 signaling pathway -1.67 3.18e-2 105/109 (96.33%) TEK;ALDOB;SERPINE1;...
Primary immunodeficiency -1.69 2.68e-2 33/38 (86.84%) TAP1;ADA;IGLL1;...
Other glycan degradation -1.70 2.28e-2 13/18 (72.22%) ENGASE;FUCA1;MAN2C1;...
Basal cell carcinoma -1.71 2.23e-2 41/63 (65.08%) GLI3;DVL3;BMP2;...
Autophagy -1.71 2.32e-2 113/169 (66.86%) ATG101;HRAS;MRAS;...
Insulin resistance -1.75 1.69e-2 96/108 (88.89%) STAT3;GFPT2;TNFRSF1A;...
Leukocyte transendothelial migration -1.75 1.60e-2 90/114 (78.95%) MSN;GNAI1;VCAM1;...
Toxoplasmosis -1.76 1.57e-2 103/112 (91.96%) LAMB3;GNAI1;IL10RB;...
Transcriptional misregulation in cancer -1.77 1.53e-2 158/192 (82.29%) MLF1;RXRB;MPO;...
Inflammatory bowel disease -1.78 1.55e-2 58/65 (89.23%) TBX21;STAT6;STAT3;...
NF-kappa B signaling pathway -1.80 1.43e-2 90/104 (86.54%) PIDD1;TNFRSF1A;CXCL12;...
Asthma -1.80 1.52e-2 25/31 (80.65%) HLA-DOB;HLA-DPB1;HLA-DRA;...
Staphylococcus aureus infection -1.80 1.47e-2 72/95 (75.79%) FCGR2B;ICAM1;DEFA4;...
Cytokine-cytokine receptor interaction -1.81 1.58e-2 246/295 (83.39%) TNFRSF12A;IL24;CCR9;...
Intestinal immune network for IgA production -1.84 7.14e-3 38/48 (79.17%) CXCL12;IL15RA;IL6;...
Phagosome -1.84 6.77e-3 118/152 (77.63%) LAMP2;TUBA1A;LAMP1;...
Steroid biosynthesis -1.86 7.39e-3 19/20 (95%) SOAT1;CYP51A1;SQLE;...
MicroRNAs in cancer -1.86 8.13e-3 146/310 (47.1%) MAP2K2;KRAS;IRS1;...
Graft-versus-host disease -1.90 7.74e-3 32/42 (76.19%) HLA-C;HLA-E;IL6;...
Viral protein interaction with cytokine and cytokine re... -1.92 5.80e-3 84/100 (84%) IL24;CCR9;PF4;...
Malaria -1.93 6.63e-3 44/50 (88%) IL18;CD81;IL6;...
Allograft rejection -1.98 3.87e-3 32/38 (84.21%) HLA-C;HLA-E;HLA-G;...
Viral myocarditis -2.05 2.32e-3 53/60 (88.33%) HLA-C;HLA-E;CASP9;...
Hematopoietic cell lineage -2.11 2.90e-3 90/99 (90.91%) CD37;CSF3R;CSF1;...
Collecting duct acid secretion -2.16 3.87e-3 22/27 (81.48%) ATP4B;ATP6V1E1;ATP4A;...
Rheumatoid arthritis -2.19 0.00e+0 78/93 (83.87%) ATP6V1F;ATP6V0D1;CSF1;...
Lysosome -2.22 0.00e+0 115/128 (89.84%) LAMP2;LAMP1;CTSZ;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H