Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMX9Y7V)

Drug Name
MEDETOMIDINE Drug Info
Cross-matching ID
PubChem CID
68602
ChEBI ID
CHEMBL77921
CAS Number
CAS 86347-14-0
TTD Drug ID
D0F2ML

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pentose and glucuronate interconversions 2.10 1.36e-2 17/34 (50%) AKR1B10;SORD;DCXR;...
Natural killer cell mediated cytotoxicity 1.98 2.03e-2 99/131 (75.57%) SHC1;GZMB;PAK1;...
Th1 and Th2 cell differentiation 1.93 2.26e-2 80/92 (86.96%) STAT4;IL2RB;IL2RG;...
T cell receptor signaling pathway 1.90 2.71e-2 93/104 (89.42%) PAK1;ITK;NFATC3;...
Propanoate metabolism 1.88 2.98e-2 30/34 (88.24%) DLD;ALDH6A1;LDHA;...
Inflammatory bowel disease 1.88 2.48e-2 58/65 (89.23%) STAT4;IL2RG;TGFB1;...
Glycolysis / Gluconeogenesis 1.84 3.29e-2 56/67 (83.58%) PFKL;DLD;PGAM1;...
Non-alcoholic fatty liver disease 1.83 3.22e-2 126/155 (81.29%) CXCL8;NDUFV2;TGFB1;...
Th17 cell differentiation 1.81 3.61e-2 95/107 (88.79%) IL2RB;IL2RG;TGFB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H