Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXB95R)

Drug Name
IC261 Drug Info
Synonyms IC-261; IC 261
Cross-matching ID
PubChem CID
5288600
ChEBI ID
CHEMBL489156
TTD Drug ID
D0UN8H

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Focal adhesion 2.08 0.00e+0 180/201 (89.55%) ITGA6;ACTN1;PDGFC;...
Hematopoietic cell lineage 2.03 0.00e+0 90/99 (90.91%) CD9;ITGA6;ITGA5;...
ECM-receptor interaction 2.01 0.00e+0 80/88 (90.91%) ITGA6;LAMC2;FN1;...
Ribosome biogenesis in eukaryotes 1.88 1.78e-2 52/108 (48.15%) NOP56;REXO2;PWP2;...
Estrogen signaling pathway 1.79 4.97e-2 119/137 (86.86%) KRT14;KRT17;HSPA8;...
Nitrogen metabolism -1.60 4.66e-2 16/17 (94.12%) GLUL;GLUD2;CPS1;...
Valine, leucine and isoleucine degradation -1.61 4.69e-2 42/48 (87.5%) ACADM;ALDH3A2;EHHADH;...
Glycolysis / Gluconeogenesis -1.61 4.78e-2 56/67 (83.58%) ALDOA;AKR1A1;ADPGK;...
Ascorbate and aldarate metabolism -1.62 4.47e-2 15/30 (50%) UGT2B4;ALDH9A1;UGT2A3;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.62 4.77e-2 20/26 (76.92%) PIGZ;PIGC;MPPE1;...
Citrate cycle (TCA cycle) -1.63 5.00e-2 30/30 (100%) ACO1;SUCLG1;SDHC;...
Sulfur metabolism -1.68 2.91e-2 9/10 (90%) SUOX;TST;SELENBP1;...
Folate biosynthesis -1.73 2.28e-2 23/26 (88.46%) GCH1;MOCS1;FPGS;...
Fatty acid degradation -1.73 2.41e-2 40/43 (93.02%) ACADM;CPT2;ACADVL;...
Thiamine metabolism -1.76 2.17e-2 12/15 (80%) ALPG;ALPL;AK2;...
Pyruvate metabolism -1.78 1.61e-2 41/47 (87.23%) ME3;PCK2;LDHB;...
DNA replication -1.79 1.61e-2 34/36 (94.44%) RFC2;PRIM1;MCM4;...
Steroid hormone biosynthesis -1.80 1.72e-2 43/61 (70.49%) CYP1A2;HSD11B1;UGT2B4;...
Tryptophan metabolism -1.82 1.88e-2 35/42 (83.33%) ALDH3A2;EHHADH;ECHS1;...
Histidine metabolism -1.85 1.29e-2 16/22 (72.73%) MAOB;ALDH3A2;ASPA;...
Tyrosine metabolism -1.88 1.21e-2 30/36 (83.33%) GOT1;FAH;HGD;...
Drug metabolism -1.90 1.34e-2 78/151 (51.66%) AOX1;GSTP1;GSTK1;...
Metabolism of xenobiotics by cytochrome P450 -2.09 0.00e+0 49/77 (63.64%) CYP3A5;GSTP1;GSTK1;...
Oxidative phosphorylation -2.33 0.00e+0 93/133 (69.92%) SDHC;ATP6V0A4;ATP5F1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.37uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H