Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXBQAM)

• Drug Name: Miglitol Drug Info
• Synonyms: Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
• Therapeutic Class: Hypoglycemic Agents
• Cross-matching ID:
  PubChem CID: 441314
  ChEBI ID: CHEMBL6935
  CAS Number: CAS 72432-03-2
  TTD Drug ID: D0D0ZD
  ACDINA Drug ID: D00433

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.06	1.10e-2	34/36 (94.44%)	PRIM1;POLE2;RFC3;...
Complement and coagulation cascades	1.89	4.40e-2	76/85 (89.41%)	C7;CLU;C1S;...
Viral protein interaction with cytokine and cytokine re...	1.85	3.67e-2	84/100 (84%)	CXCL12;CXCL1;CCL5;...
Type I diabetes mellitus	1.81	3.03e-2	38/43 (88.37%)	CPE;PTPRN2;GAD1;...
Natural killer cell mediated cytotoxicity	1.78	3.52e-2	99/131 (75.57%)	FCGR3B;LCP2;PPP3CB;...
T cell receptor signaling pathway	1.76	3.49e-2	93/104 (89.42%)	ITK;LCP2;PPP3CB;...
Rheumatoid arthritis	1.76	2.99e-2	78/93 (83.87%)	CXCL12;CXCL1;CCL5;...
Renin-angiotensin system	1.75	3.30e-2	20/23 (86.96%)	MME;ENPEP;CTSA;...
Steroid biosynthesis	1.74	3.30e-2	19/20 (95%)	MSMO1;SQLE;EBP;...
Butanoate metabolism	1.74	2.97e-2	23/28 (82.14%)	HMGCS2;ALDH5A1;ACAT2;...
Glyoxylate and dicarboxylate metabolism	1.73	3.10e-2	23/30 (76.67%)	GLDC;DLD;ACAT2;...
Staphylococcus aureus infection	1.71	3.58e-2	72/95 (75.79%)	FCGR3B;C1S;DEFB1;...
IL-17 signaling pathway	1.69	4.23e-2	84/94 (89.36%)	LCN2;S100A9;CXCL1;...
ECM-receptor interaction	-1.95	1.73e-2	80/88 (90.91%)	ITGB1;ITGA6;ITGB4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼