Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXBR27)

Drug Name
Gallopamil Drug Info
Synonyms
16662-47-8; methoxyverapamil; 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile; Galopamilo; Galopamilo [INN-Spanish]; Gallopamillum [INN-Latin]; Gallopamil [INN:BAN]; D600; D 600; C28H40N2O5; CHEBI:34772; (+/-)-Methoxyverapamil hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)valeronitrile; Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-; Methoxyverapamil; GSK 796406
Cross-matching ID
PubChem CID
1234
ChEBI ID
CHEMBL51149
CAS Number
CAS 16662-47-8
TTD Drug ID
D00ERV
VARIDT Drug ID
DR00892
INTEDE Drug ID
DR0762

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Parkinson disease 2.08 0.00e+0 176/249 (70.68%) GNAI1;GNAS;UCHL1;...
DNA replication 2.03 0.00e+0 34/36 (94.44%) MCM5;MCM2;PCNA;...
Cocaine addiction 1.98 3.72e-3 42/49 (85.71%) GNAI1;GNAS;PRKACB;...
Huntington disease 1.97 2.79e-3 233/306 (76.14%) TGM2;AP2M1;CYCS;...
Renin secretion 1.97 2.23e-3 61/69 (88.41%) GNAI1;GUCY1A1;EDNRA;...
Phenylalanine metabolism 1.83 1.30e-2 14/17 (82.35%) ALDH3A1;MAOB;GLYAT;...
Alcoholism 1.82 1.60e-2 86/186 (46.24%) SHC1;GNAI1;GNAS;...
Ferroptosis 1.81 1.54e-2 36/41 (87.8%) SLC39A8;PCBP2;SLC7A11;...
Vascular smooth muscle contraction 1.81 1.49e-2 113/133 (84.96%) GUCY1A1;EDNRA;GNAS;...
Dopaminergic synapse 1.81 1.34e-2 115/132 (87.12%) GNAI1;PPP3CA;GNAS;...
Amphetamine addiction 1.80 1.52e-2 57/69 (82.61%) PPP3CA;GNAS;PRKACB;...
Drug metabolism 1.78 1.40e-2 78/151 (51.66%) GSTP1;ALDH3A1;CES1;...
Proteasome 1.74 1.72e-2 44/46 (95.65%) PSMD11;PSMB3;PSMD3;...
Long-term depression 1.72 2.31e-2 55/60 (91.67%) GNAI1;GUCY1A1;GNAS;...
Amyotrophic lateral sclerosis 1.70 2.98e-2 267/364 (73.35%) PPP3CA;NEFM;ANG;...
Citrate cycle (TCA cycle) 1.70 2.79e-2 30/30 (100%) OGDH;CS;DLST;...
Oxytocin signaling pathway 1.70 2.82e-2 128/154 (83.12%) GNAI1;GUCY1A1;MEF2C;...
Glucagon signaling pathway 1.69 2.92e-2 89/107 (83.18%) PPP3CA;GNAS;PRKACB;...
Oxidative phosphorylation 1.69 2.76e-2 93/133 (69.92%) ATP5MC3;ATP5MC2;NDUFV2;...
Primary bile acid biosynthesis 1.69 2.62e-2 15/17 (88.24%) CH25H;AMACR;HSD17B4;...
IL-17 signaling pathway 1.67 3.03e-2 84/94 (89.36%) IL1B;CXCL2;IL17RB;...
Tryptophan metabolism 1.64 4.57e-2 35/42 (83.33%) TDO2;MAOB;ALDH8A1;...
cGMP-PKG signaling pathway 1.64 4.51e-2 145/167 (86.83%) GNAI1;GUCY1A1;EDNRA;...
Circadian entrainment 1.64 4.37e-2 85/97 (87.63%) GNAI1;GUCY1A1;GNAS;...
Protein export 1.64 4.29e-2 17/23 (73.91%) OXA1L;SRP72;SPCS1;...
Lysine degradation 1.63 4.34e-2 51/63 (80.95%) PLOD2;BBOX1;DLST;...
Valine, leucine and isoleucine degradation 1.63 4.47e-2 42/48 (87.5%) HMGCS2;ALDH3A2;ALDH1B1;...
Glycolysis / Gluconeogenesis 1.62 4.31e-2 56/67 (83.58%) ALDH3A1;GAPDH;GPI;...
Parathyroid hormone synthesis, secretion and action 1.61 4.74e-2 98/106 (92.45%) GNAI1;PDE4B;MEF2C;...
Endocrine and other factor-regulated calcium reabsorpti... 1.59 4.95e-2 49/53 (92.45%) GNAS;PRKACB;AP2M1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H