Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXBZ1D)

Drug Name
Kinetin Drug Info
Synonyms Kinerase (TN)
Cross-matching ID
PubChem CID
3830
ChEBI ID
CHEMBL228792
CAS Number
CAS 525-79-1
TTD Drug ID
D03OIW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 1.94 1.90e-2 44/46 (95.65%) PSMC6;PSMA2;PSMA3;...
Mismatch repair 1.86 2.54e-2 22/23 (95.65%) PCNA;RFC2;MSH6;...
Cell cycle 1.78 4.44e-2 110/124 (88.71%) SMC1A;TFDP1;CCNA2;...
DNA replication 1.76 3.80e-2 34/36 (94.44%) PCNA;POLE2;RFC2;...
Homologous recombination 1.76 3.55e-2 35/41 (85.37%) BARD1;NBN;POLD3;...
PPAR signaling pathway -1.86 2.80e-2 66/74 (89.19%) AQP7;CYP7A1;LPL;...
Th17 cell differentiation -1.87 2.45e-2 95/107 (88.79%) CD3G;JUN;CD3E;...
Retinol metabolism -1.92 2.33e-2 41/68 (60.29%) CYP2W1;CYP3A5;CYP3A7;...
Th1 and Th2 cell differentiation -2.00 1.40e-2 80/92 (86.96%) CD3G;JUN;CD3E;...
Mineral absorption -2.26 0.00e+0 48/60 (80%) TRPV6;ATP1A2;ATP1A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H