General Information of Drug (ID: DMXDHHH)

Drug Name
Mesna Drug Info
Synonyms Mesnex; Mexan; Mitexan; Uromitexan; Mesna, Shionogi; S-7878; 2-mercaptoethane sulfonate
Cross-matching ID
PubChem CID
23662354
ChEBI ID
CHEMBL975
CAS Number
CAS 19767-45-4
TTD Drug ID
D0C3YQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 1.71 2.42e-1 45/135 (33.33%) C7;C1QB;HLA-DQA1;...
Protein digestion and absorption 1.62 3.62e-1 78/103 (75.73%) COL14A1;COL6A1;COL6A2;...
Amoebiasis 1.60 3.31e-1 99/102 (97.06%) LAMA2;SERPINB4;SERPINB3;...
Protein export 1.58 3.00e-1 17/23 (73.91%) OXA1L;SRP54;SEC11A;...
Cytokine-cytokine receptor interaction 1.56 2.82e-1 246/295 (83.39%) CCL20;BMP2;LTB;...
Complement and coagulation cascades 1.54 2.83e-1 76/85 (89.41%) C7;C1QB;CFD;...
Tyrosine metabolism 1.52 2.96e-1 30/36 (83.33%) ADH1C;TYRP1;ADH5;...
Staphylococcus aureus infection 1.50 3.08e-1 72/95 (75.79%) DEFB1;C1QB;HLA-DQA1;...
Maturity onset diabetes of the young 1.50 2.74e-1 21/26 (80.77%) HHEX;GCK;IAPP;...
Prion disease 1.48 2.89e-1 209/273 (76.56%) C7;C1QB;NDUFS2;...
Drug metabolism 1.48 2.70e-1 78/151 (51.66%) ADH1C;ADH5;GSTT1;...
TGF-beta signaling pathway 1.47 2.53e-1 81/94 (86.17%) BMP2;ID3;ID1;...
Viral protein interaction with cytokine and cytokine re... 1.45 2.70e-1 84/100 (84%) CCL20;TNFRSF10B;CCL13;...
Malaria 1.43 2.98e-1 44/50 (88%) SDC1;SDC2;THBS2;...
Spliceosome 1.42 2.94e-1 101/150 (67.33%) SRSF6;SNRNP40;SNRPA1;...
Retinol metabolism 1.42 2.82e-1 41/68 (60.29%) ADH1C;ADH5;DHRS9;...
Rheumatoid arthritis 1.41 3.05e-1 78/93 (83.87%) CCL20;LTB;HLA-DQA1;...
Coronavirus disease 1.40 2.95e-1 215/232 (92.67%) C7;NFKBIB;RPL10;...
DNA replication 1.39 3.06e-1 34/36 (94.44%) MCM5;MCM7;POLE2;...
Pertussis 1.34 4.20e-1 64/76 (84.21%) IRAK1;C1QB;C1QA;...
Toxoplasmosis 1.32 4.44e-1 103/112 (91.96%) NFKBIB;LAMA2;IRAK1;...
Metabolism of xenobiotics by cytochrome P450 1.32 4.33e-1 49/77 (63.64%) ADH1C;ADH5;GSTT1;...
Ribosome 1.30 4.62e-1 113/158 (71.52%) RPL10;RPS27L;RPS17;...
Thyroid hormone synthesis 1.29 4.82e-1 66/75 (88%) GPX1;SERPINA7;DUOX2;...
RNA transport 1.28 4.81e-1 128/186 (68.82%) EIF1AY;NUP85;NUP62;...
Th1 and Th2 cell differentiation 1.27 4.83e-1 80/92 (86.96%) NFKBIB;NFATC3;HLA-DQA1;...
Arginine biosynthesis 1.26 5.02e-1 17/22 (77.27%) CPS1;GLS2;GLS;...
IL-17 signaling pathway 1.25 5.24e-1 84/94 (89.36%) CCL20;MUC5B;S100A7;...
NF-kappa B signaling pathway 1.24 5.23e-1 90/104 (86.54%) LTB;IRAK1;CCL13;...
Intestinal immune network for IgA production 1.23 5.24e-1 38/48 (79.17%) HLA-DQA1;CXCL12;CD40;...
Other glycan degradation -1.36 3.39e-1 13/18 (72.22%) MAN2C1;NEU1;FUCA1
Tryptophan metabolism -1.36 3.47e-1 35/42 (83.33%) KYAT1;IDO1;ALDH7A1;...
Insulin signaling pathway -1.36 3.46e-1 121/137 (88.32%) INPP5A;PRKCZ;PYGB;...
Choline metabolism in cancer -1.37 3.46e-1 84/98 (85.71%) CHPT1;MAPK3;PRKCB;...
Gastric acid secretion -1.39 3.35e-1 63/76 (82.89%) CFTR;ADCY3;KCNK10;...
Oxytocin signaling pathway -1.39 3.46e-1 128/154 (83.12%) HRAS;PPP1R12A;RHOA;...
Arrhythmogenic right ventricular cardiomyopathy -1.40 3.31e-1 70/77 (90.91%) ITGA8;ATP2A1;CACNG2;...
Thyroid cancer -1.41 3.14e-1 36/37 (97.3%) GADD45A;HRAS;GADD45G;...
Endocrine and other factor-regulated calcium reabsorpti... -1.41 3.24e-1 49/53 (92.45%) ATP2B1;RAB11A;ATP1A3;...
Regulation of lipolysis in adipocytes -1.42 3.32e-1 52/55 (94.55%) PRKACA;AKT1;ADORA1;...
Glutamatergic synapse -1.43 3.14e-1 97/114 (85.09%) SLC1A6;GNG7;SLC1A2;...
Bacterial invasion of epithelial cells -1.44 3.17e-1 59/77 (76.62%) RHOA;HCLS1;ARPC5;...
FoxO signaling pathway -1.44 3.24e-1 118/131 (90.08%) RBL2;HRAS;CDK2;...
Riboflavin metabolism -1.45 3.19e-1 7/8 (87.5%) BLVRB;RFK;ACP1;...
Lysosome -1.46 3.08e-1 115/128 (89.84%) IGF2R;CTSS;CD164;...
Aldosterone-regulated sodium reabsorption -1.50 2.45e-1 34/37 (91.89%) NEDD4L;ATP1A3;SFN;...
Glyoxylate and dicarboxylate metabolism -1.50 2.59e-1 23/30 (76.67%) MDH1;CS;PCCB;...
Endometrial cancer -1.50 2.69e-1 56/58 (96.55%) HRAS;GADD45G;SOS2;...
Biosynthesis of unsaturated fatty acids -1.50 2.92e-1 21/27 (77.78%) ACOX3;TECR;SCD;...
Mitophagy -1.52 2.65e-1 56/68 (82.35%) MFN1;UBC;MFN2;...
Ferroptosis -1.52 2.91e-1 36/41 (87.8%) FTH1;CYBB;MAP1LC3B;...
Long-term potentiation -1.54 2.72e-1 61/67 (91.04%) ITPR2;PPP3R1;BRAF;...
Nicotinate and nicotinamide metabolism -1.57 2.33e-1 25/35 (71.43%) SIRT7;NNMT;NNT;...
Propanoate metabolism -1.62 1.90e-1 30/34 (88.24%) PCCB;SUCLA2;LDHA;...
mTOR signaling pathway -1.64 1.77e-1 114/154 (74.03%) HRAS;IKBKB;RHOA;...
Synaptic vesicle cycle -1.71 1.08e-1 63/78 (80.77%) CLTB;NAPA;SLC1A6;...
Valine, leucine and isoleucine degradation -1.74 8.30e-2 42/48 (87.5%) HMGCL;ACAA1;PCCB;...
Autophagy -1.78 8.01e-2 113/169 (66.86%) ATG7;PPP2CB;ATG13;...
Collecting duct acid secretion -1.79 1.14e-1 22/27 (81.48%) ATP6V1G1;ATP6V0A2;ATP6V1D;...
PPAR signaling pathway -1.82 1.72e-1 66/74 (89.19%) ME3;NR1H3;ACSL3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H