Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXDUCP)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glutathione metabolism	-1.67	4.68e-2	43/57 (75.44%)	GSTM2;GSTM1;HPGDS;...
Malaria	-1.68	4.85e-2	44/50 (88%)	THBS2;ACKR1;GYPA;...
Hematopoietic cell lineage	-1.70	4.38e-2	90/99 (90.91%)	HLA-DQB1;FLT3LG;CD34;...
Collecting duct acid secretion	-1.71	4.72e-2	22/27 (81.48%)	ATP6V0A4;ATP6V0E2;ATP6V1E1;...
ABC transporters	-1.73	4.44e-2	37/45 (82.22%)	ABCG2;ABCB9;ABCC5;...
Histidine metabolism	-1.78	2.50e-2	16/22 (72.73%)	ALDH3A2;HDC;FTCD;...
Cytokine-cytokine receptor interaction	-1.83	1.56e-2	246/295 (83.39%)	IL15RA;INHBE;CCL22;...
Complement and coagulation cascades	-1.88	1.21e-2	76/85 (89.41%)	SERPINF2;C5AR1;F2R;...
Staphylococcus aureus infection	-1.90	1.09e-2	72/95 (75.79%)	KRT13;C1QB;KRT15;...
Renin-angiotensin system	-1.91	1.14e-2	20/23 (86.96%)	AGTR1;REN;KLK1;...
Steroid hormone biosynthesis	-1.96	3.03e-3	43/61 (70.49%)	HSD3B1;HSD3B2;CYP3A5;...
Viral protein interaction with cytokine and cytokine re...	-2.03	4.54e-3	84/100 (84%)	CCL22;CCL25;TNFRSF1A;...
Metabolism of xenobiotics by cytochrome P450	-2.20	0.00e+0	49/77 (63.64%)	CYP3A5;ADH1A;SULT2A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H