Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXDZAQ)

• Drug Name: Bepotastine Drug Info
• Synonyms: Betotastine; Tau 284; TAU-284DS; Talion (TN); (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid; 4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic acid; 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
• Therapeutic Class: Antiallergic Agents
• Cross-matching ID:
  PubChem CID: 164522
  ChEBI ID: CHEMBL71204
  CAS Number: CAS 125602-71-3
  TTD Drug ID: D0U5VZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.99	0.00e+0	34/36 (94.44%)	PCNA;FEN1;MCM2;...
TNF signaling pathway	-1.71	4.83e-2	103/112 (91.96%)	CREB5;ATF2;MAPK8;...
Th1 and Th2 cell differentiation	-1.77	4.32e-2	80/92 (86.96%)	HLA-DOA;MAPK10;PLCG1;...
Tryptophan metabolism	-1.85	1.94e-2	35/42 (83.33%)	ALDH9A1;CYP1B1;HADHA;...
NF-kappa B signaling pathway	-1.89	1.65e-2	90/104 (86.54%)	SYK;PLCG2;CFLAR;...
Neutrophil extracellular trap formation	-1.94	2.47e-3	101/189 (53.44%)	TLR8;ITGB2;PRKCA;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	-1.99	0.00e+0	79/89 (88.76%)	MAPK3;JAK1;CD247;...
IL-17 signaling pathway	-2.03	0.00e+0	84/94 (89.36%)	MAPK3;CEBPB;TNF;...
Histidine metabolism	-2.05	0.00e+0	16/22 (72.73%)	ALDH3B1;ALDH9A1;HAL;...
Primary bile acid biosynthesis	-2.11	0.00e+0	15/17 (88.24%)	AKR1C4;SCP2;AKR1D1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼