General Information of Drug (ID: DMXFZWJ)

Drug Name
BW 373U86 Drug Info
Synonyms
BW 373U86; BW-373U86; SNC-86; CHEMBL25230; 155836-50-3; BW373U86; 4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide; 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide; LBLDMHBSVIVJPM-YZIHRLCOSA-N; 150428-54-9; Tocris-1663; AC1L3O2K; (+-)-4-((alpha-R*)-alpha-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide; SCHEMBL232127; GTPL9002; CHEBI:114187; MolPort-023-276-182
Cross-matching ID
PubChem CID
119029
ChEBI ID
CHEMBL25230
CAS Number
CAS 150428-54-9
TTD Drug ID
D0K5KL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.18 0.00e+0 19/20 (95%) MSMO1;TM7SF2;SC5D;...
Homologous recombination 1.97 3.66e-3 35/41 (85.37%) RAD54B;RAD54L;MRE11;...
Glycine, serine and threonine metabolism 1.94 7.32e-3 31/40 (77.5%) CTH;SHMT1;CBS;...
Citrate cycle (TCA cycle) 1.74 4.03e-2 30/30 (100%) SUCLG1;DLST;IDH1;...
Epstein-Barr virus infection -1.62 4.42e-2 189/202 (93.56%) TRAF6;SNW1;MDM2;...
Basal cell carcinoma -1.63 4.49e-2 41/63 (65.08%) DDB2;TP53;APC;...
T cell receptor signaling pathway -1.64 4.35e-2 93/104 (89.42%) CTLA4;PTPRC;PDPK1;...
TGF-beta signaling pathway -1.65 3.97e-2 81/94 (86.17%) TGFB2;BMPR1A;TGFBR1;...
Human T-cell leukemia virus 1 infection -1.65 4.13e-2 197/219 (89.95%) TGFB2;PRKACA;TGFBR1;...
Ferroptosis -1.66 3.57e-2 36/41 (87.8%) SLC7A11;ACSL4;TP53;...
Retinol metabolism -1.67 3.52e-2 41/68 (60.29%) UGT2A3;DHRS9;CYP2C18;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.67 3.56e-2 79/89 (88.76%) CSNK2A2;CHUK;ZAP70;...
Transcriptional misregulation in cancer -1.71 2.30e-2 158/192 (82.29%) IL2RB;PTK2;BCL2L1;...
AGE-RAGE signaling pathway in diabetic complications -1.71 2.41e-2 97/100 (97%) TGFB2;TGFBR1;COL1A2;...
Cytokine-cytokine receptor interaction -1.72 2.23e-2 246/295 (83.39%) CXCR1;CXCR3;IL19;...
Viral myocarditis -1.73 1.90e-2 53/60 (88.33%) HLA-DOB;CD40;CCND1;...
NF-kappa B signaling pathway -1.75 1.54e-2 90/104 (86.54%) BIRC2;TRAF1;TRAF6;...
Chronic myeloid leukemia -1.79 9.22e-3 72/76 (94.74%) GRB2;SHC1;MDM2;...
IL-17 signaling pathway -1.79 9.79e-3 84/94 (89.36%) CCL2;TNF;CXCL10;...
Staphylococcus aureus infection -1.82 8.04e-3 72/95 (75.79%) C1QB;FPR1;KRT17;...
Hematopoietic cell lineage -1.86 4.31e-3 90/99 (90.91%) CD8A;CD37;CD34;...
Viral protein interaction with cytokine and cytokine re... -1.92 9.27e-4 84/100 (84%) IL2RG;CCL2;CCR2;...
Leishmaniasis -1.93 1.00e-3 67/77 (87.01%) TNF;IFNGR2;HLA-DOB;...
Autoimmune thyroid disease -1.94 1.10e-3 46/53 (86.79%) HLA-F;CGA;HLA-DOB;...
Bladder cancer -1.96 1.21e-3 40/41 (97.56%) E2F3;MAP2K1;TP53;...
Th1 and Th2 cell differentiation -1.97 1.34e-3 80/92 (86.96%) IL2RB;CD3E;CD3D;...
Th17 cell differentiation -2.02 0.00e+0 95/107 (88.79%) SMAD3;TGFB1;AHR;...
Complement and coagulation cascades -2.09 0.00e+0 76/85 (89.41%) C1QA;SERPINF2;C8G;...
Inflammatory bowel disease -2.12 0.00e+0 58/65 (89.23%) TLR5;STAT6;TGFB2;...
Graft-versus-host disease -2.13 0.00e+0 32/42 (76.19%) HLA-F;TNF;HLA-DOB;...
Systemic lupus erythematosus -2.20 0.00e+0 45/135 (33.33%) C1QA;C8G;C1QB;...
Allograft rejection -2.22 0.00e+0 32/38 (84.21%) HLA-F;TNF;HLA-DOB;...
Type I diabetes mellitus -2.29 0.00e+0 38/43 (88.37%) HLA-F;TNF;HLA-DOB;...
Asthma -2.40 0.00e+0 25/31 (80.65%) TNF;FCER1A;HLA-DOB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H