Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXFZZB)

Drug Name
Tofogliflozin Drug Info
Synonyms
TOFOGLIFLOZIN; 903565-83-3; CSG 452; Tofogliflozin anhydrous; UNII-554245W62T; CSG-452; 554245W62T; deberza; apleway; Tofogliflozin [INN]; R-7201; Tofogliflozin anyhydrous; Tube107; EC 619-989-0; SCHEMBL903156; GTPL9395; CHEMBL2110731; DTXSID90238097; CSG452;CSG-452; CHEBI:136041; MolPort-044-723-920; ZINC35826342; BDBM50396779; AKOS027250822; DB11824; SB11170; compound 16d [PMID: 22889351]; NCGC00485920-01; KB-76204
Cross-matching ID
PubChem CID
46908929
ChEBI ID
CHEMBL2110731
CAS Number
CAS 903565-83-3
TTD Drug ID
D04DXA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 2.46 0.00e+0 72/95 (75.79%) KRT19;HLA-DRA;HLA-DQA1;...
Complement and coagulation cascades 2.19 0.00e+0 76/85 (89.41%) CLU;PLAT;CFB;...
DNA replication 2.16 0.00e+0 34/36 (94.44%) MCM4;POLE2;RFC4;...
p53 signaling pathway 2.02 0.00e+0 63/73 (86.3%) RRM2;TNFRSF10B;CCNE2;...
Systemic lupus erythematosus 2.01 0.00e+0 45/135 (33.33%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Graft-versus-host disease 1.97 2.16e-3 32/42 (76.19%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Toxoplasmosis 1.93 3.71e-3 103/112 (91.96%) HLA-DRA;HLA-DQA1;BAD;...
Glutathione metabolism 1.91 4.86e-3 43/57 (75.44%) CHAC1;RRM2;GSTM3;...
Phagosome 1.90 4.32e-3 118/152 (77.63%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Allograft rejection 1.88 5.19e-3 32/38 (84.21%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Leishmaniasis 1.87 4.72e-3 67/77 (87.01%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Ferroptosis 1.86 5.41e-3 36/41 (87.8%) SLC39A8;FTH1;ACSL1;...
Mineral absorption 1.85 6.99e-3 48/60 (80%) MT1X;MT2A;FTH1;...
Influenza A 1.84 7.41e-3 156/172 (90.7%) HLA-DRA;TNFRSF10B;HLA-DQA1;...
Autoimmune thyroid disease 1.83 8.65e-3 46/53 (86.79%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Steroid biosynthesis 1.83 8.11e-3 19/20 (95%) DHCR7;SQLE;MSMO1;...
Drug metabolism 1.83 7.63e-3 78/151 (51.66%) RRM2;GSTM3;ADH1B;...
Intestinal immune network for IgA production 1.82 8.65e-3 38/48 (79.17%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Metabolism of xenobiotics by cytochrome P450 1.79 1.30e-2 49/77 (63.64%) CYP1B1;GSTM3;ADH1B;...
Fanconi anemia pathway 1.77 1.56e-2 36/54 (66.67%) HES1;RAD51C;USP1;...
Epstein-Barr virus infection 1.76 1.73e-2 189/202 (93.56%) HLA-DRA;CCNE2;HLA-DQA1;...
Asthma 1.74 1.77e-2 25/31 (80.65%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Type I diabetes mellitus 1.73 2.20e-2 38/43 (88.37%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Viral myocarditis 1.70 2.76e-2 53/60 (88.33%) HLA-DRA;HLA-DQA1;HLA-DPA1;...
Retinol metabolism 1.67 3.53e-2 41/68 (60.29%) ADH1B;ALDH1A2;CYP3A4;...
Synthesis and degradation of ketone bodies 1.66 4.09e-2 9/10 (90%) HMGCS1;ACAT2;OXCT1;...
Protein digestion and absorption 1.65 4.13e-2 78/103 (75.73%) COL14A1;COL11A1;COL6A2;...
Cholesterol metabolism 1.65 4.03e-2 44/50 (88%) NPC1;LRPAP1;PLTP;...
Mismatch repair 1.65 4.03e-2 22/23 (95.65%) RFC4;POLD3;RFC5;...
Nucleotide excision repair 1.64 4.15e-2 40/47 (85.11%) DDB2;POLE2;RFC4;...
mRNA surveillance pathway -1.82 1.19e-2 71/98 (72.45%) CPSF4;ACIN1;NXF2;...
Nitrogen metabolism -1.83 1.78e-2 16/17 (94.12%) CA12;CA2;CA6;...
Spliceosome -1.86 1.78e-2 101/150 (67.33%) DDX5;SF3B3;SF3B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H