Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXGDFK)

Drug Name
FENBUFEN Drug Info
Synonyms
fenbufen; 36330-85-5; Lederfen; Cinopal; Napanol; Bufemid; 4-(4-Biphenylyl)-4-oxobutyric acid; 3-(4-Phenylbenzoyl)propionic acid; 3-(4-Biphenylylcarbonyl)propionic acid; 4-(biphenyl-4-yl)-4-oxobutanoic acid; gamma-Oxo(1,1'-biphenyl)-4-butanoic acid; 3-(4-Biphenylcarbonyl)propionic acid; Cinopol; Fenbufenum [INN-Latin]; Fenbufene [INN-French]; 4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid; CL-82204; CL 82204; 4-biphenyl-4-yl-4-oxobutanoic acid; Butyric acid 4-(4-biphenyl)-4-oxo-; UNII-9815R1WR9B; 4-oxo-4-(4-phenylphenyl)butanoic a
Cross-matching ID
PubChem CID
3335
ChEBI ID
CHEMBL31599
CAS Number
CAS 36330-85-5
TTD Drug ID
D06LHG
VARIDT Drug ID
DR01176

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Phenylalanine metabolism 2.21 0.00e+0 14/17 (82.35%) MAOB;PAH;HPD;...
DNA replication 2.09 4.33e-3 34/36 (94.44%) RNASEH2A;RFC2;POLD4;...
Tyrosine metabolism 2.08 2.88e-3 30/36 (83.33%) MAOB;TYRP1;HPD;...
Aminoacyl-tRNA biosynthesis 1.90 1.08e-2 15/66 (22.73%) DARS2;GATC;FARS2;...
Lysine degradation 1.81 1.90e-2 51/63 (80.95%) BBOX1;MECOM;PIPOX;...
Fanconi anemia pathway 1.78 2.45e-2 36/54 (66.67%) BLM;RPA3;RAD51;...
Tryptophan metabolism 1.76 2.60e-2 35/42 (83.33%) MAOB;KMO;ALDH3A2;...
Folate biosynthesis 1.75 2.38e-2 23/26 (88.46%) PAH;GGH;ALPL;...
Homologous recombination 1.72 2.69e-2 35/41 (85.37%) POLD4;RBBP8;BLM;...
Mismatch repair 1.72 2.42e-2 22/23 (95.65%) EXO1;RFC2;POLD4;...
Rheumatoid arthritis -1.68 4.45e-2 78/93 (83.87%) TLR4;TLR2;MMP3;...
Phagosome -1.69 4.82e-2 118/152 (77.63%) TLR4;TLR2;NCF4;...
Amoebiasis -1.70 4.75e-2 99/102 (97.06%) PTK2;RAB5B;CD1B;...
Pancreatic secretion -1.71 4.89e-2 87/102 (85.29%) PLCB2;PLA2G1B;PRSS1;...
B cell receptor signaling pathway -1.73 4.59e-2 71/81 (87.65%) LILRA1;CD22;PPP3CB;...
Neutrophil extracellular trap formation -1.74 4.92e-2 101/189 (53.44%) TLR4;TLR7;TLR2;...
Protein processing in endoplasmic reticulum -1.81 2.41e-2 127/171 (74.27%) NSFL1C;EIF2AK1;LMAN2;...
Hematopoietic cell lineage -1.82 2.45e-2 90/99 (90.91%) EPOR;CD1A;CD22;...
Porphyrin and chlorophyll metabolism -1.82 3.06e-2 23/43 (53.49%) CPOX;BLVRA;ALAD;...
Lysosome -1.86 2.22e-2 115/128 (89.84%) ATP6V0A4;HGSNAT;ATP6V1H;...
Other glycan degradation -1.86 3.34e-2 13/18 (72.22%) MAN2B1;MAN2C1;GLB1;...
Legionellosis -1.92 3.34e-2 51/57 (89.47%) CASP9;TLR5;CASP7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H