Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXGQYZ)

• Drug Name: Fleroxacin Drug Info
• Synonyms: FLRX; Fleroxacine; Fleroxacino; Fleroxacinum; Fleroxicin; Megalocin; Megalone; Megalosin; Quinodis; Fleroxacine [French]; Fleroxacino [Spanish]; Fleroxacinum [Latin]; AM 833; F0646; AM-833; Megalocin (TN); Megalone (TN); Quinodis (TN); Ro 23-6240; Ro-236240; Ro 23-6240/000; Fleroxacin (JAN/USAN/INN); Fleroxacin [USAN:BAN:INN:JAN]; Ro-23-6240/000; 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid; 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 3357
  ChEBI ID: CHEMBL6273
  CAS Number: CAS 79660-72-3
  TTD Drug ID: D06GAM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Systemic lupus erythematosus	2.16	0.00e+0	45/135 (33.33%)	HLA-DRA;C1QA;C1QB;...
Asthma	2.00	2.32e-2	25/31 (80.65%)	HLA-DRA;HLA-DPA1;HLA-DQB1;...
Mineral absorption	1.98	1.55e-2	48/60 (80%)	MT1X;TF;MT2A;...
Notch signaling pathway	-1.84	3.63e-2	49/59 (83.05%)	MAML1;CIR1;DVL3;...
Cardiac muscle contraction	-1.93	1.61e-2	64/87 (73.56%)	ATP1B1;ATP2A1;CASQ2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Hide ▲