Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXJB4N)

Drug Name
BMS-536924 Drug Info
Cross-matching ID
PubChem CID
135440466
ChEBI ID
CHEMBL401930
CAS Number
CAS 468740-43-4
TTD Drug ID
D0M4SY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Inositol phosphate metabolism 2.05 0.00e+0 66/73 (90.41%) IMPA2;PLCB4;PLCB1;...
Glycosaminoglycan degradation 1.91 1.02e-2 19/19 (100%) GUSB;HEXA;GLB1;...
Phosphatidylinositol signaling system 1.88 6.82e-3 82/97 (84.54%) IMPA2;PLCB4;PLCB1;...
Sulfur metabolism 1.86 5.11e-3 9/10 (90%) TST;MPST;SELENBP1;...
Notch signaling pathway 1.83 4.09e-3 49/59 (83.05%) CREBBP;TLE4;DTX4;...
TNF signaling pathway -1.62 4.95e-2 103/112 (91.96%) IL18R1;MAP3K7;CFLAR;...
Bladder cancer -1.63 4.64e-2 40/41 (97.56%) MAP2K1;MAPK1;MMP1;...
Prion disease -1.65 4.10e-2 209/273 (76.56%) PSMC2;PSMB1;CREB5;...
Hematopoietic cell lineage -1.71 2.27e-2 90/99 (90.91%) CD36;CSF3;CD2;...
Ferroptosis -1.71 2.16e-2 36/41 (87.8%) ACSL3;STEAP3;ACSL4;...
Colorectal cancer -1.73 2.10e-2 84/86 (97.67%) MAPK9;RHOA;AXIN1;...
Terpenoid backbone biosynthesis -1.77 1.36e-2 18/22 (81.82%) FDPS;PDSS1;ACAT2;...
NF-kappa B signaling pathway -1.78 1.39e-2 90/104 (86.54%) TNFAIP3;IL1R1;IRAK1;...
IL-17 signaling pathway -1.80 1.34e-2 84/94 (89.36%) TRAF4;IL17RC;HSP90AB1;...
Spliceosome -1.80 1.37e-2 101/150 (67.33%) SF3B5;PRPF19;SNRPD3;...
Rheumatoid arthritis -1.81 1.20e-2 78/93 (83.87%) IFNG;ANGPT1;ATP6V0C;...
RNA polymerase -1.82 1.35e-2 23/31 (74.19%) POLR3E;POLR2L;POLR2F;...
Glycosaminoglycan biosynthesis -1.88 5.61e-3 40/58 (68.97%) CSGALNACT2;HS3ST2;B3GNT2;...
RNA transport -1.88 6.54e-3 128/186 (68.82%) SUMO1;EIF4A1;NUP37;...
Biosynthesis of unsaturated fatty acids -1.93 1.96e-3 21/27 (77.78%) FADS2;HSD17B12;ELOVL6;...
Legionellosis -2.00 2.45e-3 51/57 (89.47%) NFKB1;CASP7;TLR2;...
Proteasome -2.19 0.00e+0 44/46 (95.65%) PSMC2;PSMB1;PSMB3;...
Steroid biosynthesis -2.24 0.00e+0 19/20 (95%) HSD17B7;LSS;FDFT1;...
Ribosome biogenesis in eukaryotes -2.43 0.00e+0 52/108 (48.15%) TBL3;TCOF1;IMP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 12uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 12uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 12uM 6H
HT-29 CVCL_0320 Homo sapiens 0.05uM - 12uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 12uM 6H
MDST8 CVCL_1400 Homo sapiens 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 12uM 6H
SW480 CVCL_0546 Homo sapiens 12uM 6H
SW620 CVCL_0547 Homo sapiens 12uM 6H
SW948 CVCL_0550 Homo sapiens 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 12uM 6H
HT115 CVCL_1294 Homo sapiens 12uM 6H
RKO CVCL_0504 Homo sapiens 12uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 12uM 6H
SNG-M CVCL_1707 Homo sapiens 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 12uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.05uM - 12uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.05uM - 12uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 12uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 12uM 6H
HCC515 CVCL_5134 Homo sapiens 0.05uM - 12uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 12uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 12uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 12uM 6H
OV7 CVCL_1623 Homo sapiens 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 12uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 12uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 12uM 6H
PL-21 CVCL_2161 Homo sapiens 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 12uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.05uM - 12uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 12uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.05uM - 12uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 12uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 12uM 6H