Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXJMKF)

Drug Name
Ganaxolone Drug Info
Synonyms
Ganaxolone [USAN]; CCD 1042; CCD-1042; Ganaxolone (USAN/INN); (3alpha,5alpha)-3-Hydroxy-3-methylpregnan-20-one; 1-[(3R,5S,10S,13S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 3alpha-Hydroxy-3-methyl-5alpha-pregnan-20-one; 3alpha-Hydroxy-3beta-methyl-5alpha-pregnan-20-one
Cross-matching ID
PubChem CID
6918305
ChEBI ID
CHEMBL1568698
CAS Number
CAS 38398-32-2
TTD Drug ID
D0X0CH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cholesterol metabolism -1.63 3.43e-2 44/50 (88%) ABCA1;LIPC;APOA1;...
NOD-like receptor signaling pathway -1.64 3.26e-2 145/181 (80.11%) NLRX1;ITPR3;TAB1;...
Lipid and atherosclerosis -1.66 2.99e-2 190/215 (88.37%) PIK3CB;HSPA4;PTK2;...
Glycosaminoglycan degradation -1.66 3.10e-2 19/19 (100%) HYAL4;HEXA;HPSE;...
Ferroptosis -1.68 2.90e-2 36/41 (87.8%) CP;SLC39A14;GSS;...
Tryptophan metabolism -1.69 2.87e-2 35/42 (83.33%) ALDH9A1;KYAT1;GCDH;...
African trypanosomiasis -1.70 2.44e-2 32/37 (86.49%) GNAQ;HPR;PLCB1;...
T cell receptor signaling pathway -1.70 2.50e-2 93/104 (89.42%) DLG1;PIK3CB;GSK3B;...
Peroxisome -1.72 2.01e-2 72/82 (87.8%) SLC27A2;DAO;AMACR;...
beta-Alanine metabolism -1.73 2.11e-2 25/30 (83.33%) ALDH9A1;DPYS;ECHS1;...
Histidine metabolism -1.73 2.21e-2 16/22 (72.73%) HAL;ALDH9A1;ALDH3A1;...
Arachidonic acid metabolism -1.76 1.76e-2 48/61 (78.69%) CBR3;GGT1;PTGS2;...
Arginine biosynthesis -1.78 1.40e-2 17/22 (77.27%) ARG1;GOT1;GLUD1;...
Viral protein interaction with cytokine and cytokine re... -1.79 1.41e-2 84/100 (84%) TNFRSF1B;CCR1;ACKR4;...
Cysteine and methionine metabolism -1.79 1.50e-2 43/50 (86%) PHGDH;BHMT2;CBS;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.81 1.44e-2 79/89 (88.76%) ZAP70;EGFR;RASGRP1;...
Steroid hormone biosynthesis -1.81 1.54e-2 43/61 (70.49%) COMT;HSD17B2;UGT2B15;...
Glycine, serine and threonine metabolism -1.83 1.47e-2 31/40 (77.5%) SHMT1;SRR;SHMT2;...
Arginine and proline metabolism -1.87 1.30e-2 39/50 (78%) GOT2;SRM;ALDH9A1;...
Drug metabolism -1.88 1.20e-2 78/151 (51.66%) FMO5;UGT2B15;UCK2;...
Glyoxylate and dicarboxylate metabolism -1.88 1.32e-2 23/30 (76.67%) AGXT;MMUT;ACAT1;...
Alanine, aspartate and glutamate metabolism -1.90 1.06e-2 27/37 (72.97%) GFPT2;GOT1;GLUD1;...
Primary immunodeficiency -1.92 1.20e-2 33/38 (86.84%) TAP2;IL2RG;ZAP70;...
Fatty acid degradation -1.96 1.20e-2 40/43 (93.02%) EHHADH;ACSBG1;ACAT1;...
Mineral absorption -2.01 5.98e-3 48/60 (80%) HEPH;HMOX1;MT1G;...
Metabolism of xenobiotics by cytochrome P450 -2.03 4.79e-3 49/77 (63.64%) UGT2B15;CYP2D6;ADH6;...
Linoleic acid metabolism -2.09 5.98e-3 21/29 (72.41%) CYP2J2;CYP2C8;CYP3A4;...
Porphyrin and chlorophyll metabolism -2.09 7.98e-3 23/43 (53.49%) BLVRA;UGT2B15;FECH;...
Complement and coagulation cascades -2.17 5.98e-3 76/85 (89.41%) CFHR5;PLG;C8G;...
Retinol metabolism -2.44 0.00e+0 41/68 (60.29%) UGT2B15;ALDH1A3;CYP3A7;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H