Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXKDUL)

Drug Name
BGT226 Drug Info
Synonyms
BGT-226 free base; 915020-55-2; UNII-ZXE7F2GMJJ; BGT226 free base; ZXE7F2GMJJ; BGT-226; 8-(6-Methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-trifluoromethylphenyl]-1,3-dihydroimidazo[4,5-c]quinolin-2-one; CHEBI:71967; BGT 226; NVPBGT226; 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 8-(6-Methoxy-pyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl-3-trifluoromethyl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one; NPV-BGT226; SCHEMBL146939
Cross-matching ID
PubChem CID
11978790
ChEBI ID
CHEMBL3218578
CAS Number
CAS 915020-55-2
TTD Drug ID
D0X7IN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
SNARE interactions in vesicular transport 1.92 1.03e-2 19/33 (57.58%) STX1A;STX7;STX16;...
ECM-receptor interaction 1.82 3.10e-2 80/88 (90.91%) ITGA3;LAMC2;ITGB4;...
Viral carcinogenesis -1.67 3.31e-2 149/203 (73.4%) TBPL1;BAX;YWHAH;...
p53 signaling pathway -1.68 3.23e-2 63/73 (86.3%) TNFRSF10B;BID;SFN;...
Human immunodeficiency virus 1 infection -1.68 3.30e-2 189/212 (89.15%) PAK4;AKT2;RAC3;...
Proximal tubule bicarbonate reclamation -1.69 3.06e-2 21/23 (91.3%) ATP1A1;CA2;MDH1;...
Thermogenesis -1.69 2.91e-2 173/232 (74.57%) NDUFS4;SMARCA4;ACTL6A;...
Drug metabolism -1.70 2.98e-2 78/151 (51.66%) ADH6;GSTM1;GSTM2;...
Aldosterone-regulated sodium reabsorption -1.74 1.84e-2 34/37 (91.89%) ATP1A1;SFN;PRKCB;...
Fatty acid degradation -1.75 1.38e-2 40/43 (93.02%) ACADM;ADH6;HADH;...
Prion disease -1.75 1.38e-2 209/273 (76.56%) CYC1;ATP5F1C;TNF;...
Glycolysis / Gluconeogenesis -1.77 1.31e-2 56/67 (83.58%) PFKM;ENO3;TPI1;...
Cell cycle -1.78 1.24e-2 110/124 (88.71%) CDC45;CHEK2;E2F3;...
Valine, leucine and isoleucine degradation -1.78 1.23e-2 42/48 (87.5%) ACADM;HADH;HMGCS2;...
Protein processing in endoplasmic reticulum -1.79 1.07e-2 127/171 (74.27%) EIF2AK3;BAG2;SEC62;...
Parkinson disease -1.83 8.10e-3 176/249 (70.68%) GNAI2;NDUFS4;NDUFB4;...
Antigen processing and presentation -1.86 5.17e-3 60/78 (76.92%) HLA-DPA1;IFI30;TNF;...
Pyruvate metabolism -1.89 4.59e-3 41/47 (87.23%) PDHA1;ADH6;FH;...
Metabolism of xenobiotics by cytochrome P450 -1.90 2.95e-3 49/77 (63.64%) GSTA3;ADH6;GSTM1;...
PPAR signaling pathway -1.91 3.18e-3 66/74 (89.19%) ANGPTL4;ACADM;FABP4;...
Butanoate metabolism -1.91 3.44e-3 23/28 (82.14%) GAD2;HADH;HMGCS2;...
DNA replication -1.92 3.76e-3 34/36 (94.44%) LIG1;PRIM2;RFC5;...
Glycine, serine and threonine metabolism -1.96 4.13e-3 31/40 (77.5%) ALAS1;MAOB;SRR;...
Terpenoid backbone biosynthesis -1.96 4.59e-3 18/22 (81.82%) ICMT;FDPS;HMGCR;...
Propanoate metabolism -1.97 5.17e-3 30/34 (88.24%) DBT;ACAT1;EHHADH;...
Citrate cycle (TCA cycle) -1.99 3.94e-3 30/30 (100%) PDHA1;ACO2;FH;...
Glyoxylate and dicarboxylate metabolism -2.04 2.30e-3 23/30 (76.67%) ACO2;HAO2;GLUL;...
Glutathione metabolism -2.04 2.75e-3 43/57 (75.44%) GGCT;GCLC;GPX3;...
Diabetic cardiomyopathy -2.06 3.44e-3 162/203 (79.8%) MPC1;NDUFS4;PDHA1;...
Oxidative phosphorylation -2.08 0.00e+0 93/133 (69.92%) COX6A1;COX6A2;NDUFS1;...
Biosynthesis of unsaturated fatty acids -2.15 0.00e+0 21/27 (77.78%) ACOT7;HSD17B12;HSD17B4;...
Steroid biosynthesis -2.63 0.00e+0 19/20 (95%) LIPA;LSS;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 3.33uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 3.33uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 0.12uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 1.11uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 3.33uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 3.33uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 3.33uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 0.37uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H