Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXON4L)

Drug Name
CB-676475 Drug Info
Synonyms
690206-97-4; ZM 306416; ZM306416; ZM-306416; N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine; ZM-306416(CB 676475); CB-676475; CHEMBL150315; AK174923; CB 676475; Anilinoquinazoline deriv. 4; AC1NS5UJ; SCHEMBL3012896; BDBM4621; GTPL8245; CTK8E8823; CHEBI:92732; DTXSID90416176; AOB6790; MolPort-035-395-727; HMS3651N06; BCP06445; ZINC2583789; HSCI1_000042; s2897; 2820AH; AKOS025404926; SB16593; CS-1349; KS-00000T57; NCGC00167747-01; SC-95590; DA-41680; CB676475; HY-13785; AB0165814; RT-016341; KB-299318; SW219943-1; FT-0706412; S-7773
Cross-matching ID
PubChem CID
5329006
ChEBI ID
CHEMBL150315
CAS Number
CAS 690206-97-4
TTD Drug ID
D0C6KI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Propanoate metabolism 2.10 0.00e+0 30/34 (88.24%) ABAT;ACAT2;DLD;...
Butanoate metabolism 1.81 4.42e-2 23/28 (82.14%) ABAT;ACSM3;ACAT2;...
Valine, leucine and isoleucine degradation 1.80 3.31e-2 42/48 (87.5%) ABAT;ACAT2;DLD;...
Steroid biosynthesis 1.77 3.88e-2 19/20 (95%) DHCR24;FDFT1;LIPA;...
Nicotinate and nicotinamide metabolism 1.76 3.40e-2 25/35 (71.43%) QPRT;NT5C2;NMRK1;...
Porphyrin and chlorophyll metabolism 1.74 3.64e-2 23/43 (53.49%) CP;HEPH;ALAS2;...
beta-Alanine metabolism 1.74 3.19e-2 25/30 (83.33%) ABAT;ACOX1;DPYS;...
Aldosterone-regulated sodium reabsorption 1.73 3.17e-2 34/37 (91.89%) FXYD2;KRAS;PRKCB;...
Central carbon metabolism in cancer 1.72 3.47e-2 67/70 (95.71%) FGFR3;KRAS;ERBB2;...
Renin-angiotensin system 1.68 4.54e-2 20/23 (86.96%) AGT;CPA3;REN;...
Mineral absorption -1.67 4.24e-2 48/60 (80%) TF;HMOX1;MT2A;...
PPAR signaling pathway -1.69 3.91e-2 66/74 (89.19%) ME1;FADS2;FABP7;...
N-Glycan biosynthesis -1.69 4.21e-2 38/50 (76%) ALG12;ALG13;MGAT4A;...
Spliceosome -1.74 2.61e-2 101/150 (67.33%) SF3B1;LSM6;PRPF38B;...
Viral protein interaction with cytokine and cytokine re... -1.77 1.83e-2 84/100 (84%) CCR6;CSF1;IL10RA;...
Rheumatoid arthritis -1.85 5.59e-3 78/93 (83.87%) IL1A;ACP5;IL18;...
Ribosome biogenesis in eukaryotes -1.88 6.52e-3 52/108 (48.15%) DROSHA;RIOK2;BMS1;...
IL-17 signaling pathway -1.88 7.82e-3 84/94 (89.36%) IL13;TRAF3IP2;TBK1;...
Hematopoietic cell lineage -1.88 7.34e-3 90/99 (90.91%) IL1A;IL5;CD9;...
Cytokine-cytokine receptor interaction -1.90 9.78e-3 246/295 (83.39%) TNFSF11;IL13RA1;IL1R1;...
Ferroptosis -1.95 9.78e-3 36/41 (87.8%) PCBP2;FTL;GCLM;...
Protein processing in endoplasmic reticulum -1.95 9.78e-3 127/171 (74.27%) NGLY1;HSPA6;CAPN2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H