Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXQ1K0)

• Drug Name: 7,4'-Dihydroxyflavone Drug Info
• Synonyms: 7,4'-Dihydroxyflavone; 4',7-Dihydroxyflavone; 2196-14-7; 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-; FLAVONE, 4',7-DIHYDROXY-; UNII-53ZZF57X0U; CHEMBL294878; 53ZZF57X0U; 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one; CHEBI:29503; LCAWNFIFMLXZPQ-UHFFFAOYSA-N; BRN 0224356; PubChem9844; AC1NQZG5; 7, 4'-Dihydroxyflavone; Spectrum4_001280; 7,4''-Dihydroxyflavone; 7,4' - Dihydroxyflavone; C12123; 7,4&#39-dihydroxyflavone; KBioGR_001900; SPECTRUM1500721; SCHEMBL157723
• Cross-matching ID:
  PubChem CID: 5282073
  ChEBI ID: CHEMBL294878
  CAS Number: CAS 2196-14-7
  TTD Drug ID: D0SY6C

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Fanconi anemia pathway	1.86	3.14e-2	36/54 (66.67%)	BLM;FANCI;RAD51;...
Focal adhesion	-1.79	3.40e-2	180/201 (89.55%)	TLN1;MAPK10;RAP1B;...
HIF-1 signaling pathway	-1.81	2.40e-2	105/109 (96.33%)	PIK3CA;ARNT;SERPINE1;...
Neutrophil extracellular trap formation	-1.82	2.80e-2	101/189 (53.44%)	NCF4;FCGR2A;MPO;...
Osteoclast differentiation	-1.82	3.11e-2	117/127 (92.13%)	FCGR2C;JUND;FOSB;...
Mineral absorption	-1.83	2.91e-2	48/60 (80%)	MT1HL1;FTL;FTH1;...
Bacterial invasion of epithelial cells	-1.84	3.45e-2	59/77 (76.62%)	ARPC1B;ARHGAP10;PIK3CB;...
Antigen processing and presentation	-1.87	1.94e-2	60/78 (76.92%)	KLRD1;CIITA;HSP90AB1;...
Amphetamine addiction	-1.88	3.88e-2	57/69 (82.61%)	FOSB;CREB3L1;CREB3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼