Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXRU72)

Drug Name
SEP-227900 Drug Info
Cross-matching ID
PubChem CID
7141881
TTD Drug ID
D0XW4W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.03 6.38e-3 101/150 (67.33%) HSPA8;LSM5;HNRNPA1;...
DNA replication 2.00 3.19e-3 34/36 (94.44%) PCNA;FEN1;MCM7;...
Ribosome biogenesis in eukaryotes 1.89 1.06e-2 52/108 (48.15%) HEATR1;NOP56;NXF1;...
One carbon pool by folate 1.78 3.03e-2 15/20 (75%) TYMS;MTHFD1;SHMT1;...
Fructose and mannose metabolism -1.68 4.17e-2 30/33 (90.91%) PFKP;GMPPA;GMDS;...
T cell receptor signaling pathway -1.69 3.56e-2 93/104 (89.42%) FYN;IKBKG;MAPK3;...
Osteoclast differentiation -1.70 2.69e-2 117/127 (92.13%) IFNG;LILRA1;LILRB5;...
Glycolysis / Gluconeogenesis -1.71 2.28e-2 56/67 (83.58%) GAPDHS;PFKP;AKR1A1;...
Chemokine signaling pathway -1.74 1.71e-2 163/192 (84.9%) BAD;GRK6;CCL19;...
Fluid shear stress and atherosclerosis -1.76 1.50e-2 123/139 (88.49%) IL1B;GSTM5;NFKB1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.77 1.52e-2 62/70 (88.57%) ATP6V0C;RAC1;ATP6V1G1;...
Mitophagy -1.77 1.53e-2 56/68 (82.35%) CSNK2B;RELA;HRAS;...
Pentose phosphate pathway -1.80 1.23e-2 25/30 (83.33%) PRPS1;PFKP;PGD;...
Tyrosine metabolism -1.81 1.39e-2 30/36 (83.33%) HPD;FAH;MIF;...
Hematopoietic cell lineage -1.81 1.59e-2 90/99 (90.91%) FCER2;IL1B;CD7;...
TNF signaling pathway -1.81 1.85e-2 103/112 (91.96%) CEBPB;IFNB1;CREB3L1;...
B cell receptor signaling pathway -1.86 1.39e-2 71/81 (87.65%) LILRA1;PTPN6;LILRB5;...
C-type lectin receptor signaling pathway -1.88 1.39e-2 93/104 (89.42%) IL6;IKBKG;ARHGEF12;...
Rheumatoid arthritis -1.90 1.85e-2 78/93 (83.87%) HLA-DOA;HLA-DRA;ATP6V0A4;...
Amino sugar and nucleotide sugar metabolism -1.96 0.00e+0 38/48 (79.17%) GALK1;NANS;GCK;...
Bladder cancer -2.06 0.00e+0 40/41 (97.56%) NRAS;FGFR3;THBS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H