Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXYJOB)

• Drug Name: Phentolamine Drug Info
• Synonyms: Dibasin; Fentolamin; Fentolamina; Phenotolamine; Phentalamine; Phentolaminum; Regitin; Regitine; Regitipe; Regityn; Rogitine; Phentolamine mesylate [USAN]; Phentolamine methanesulfonate; C 7337; C 7337 Ciba; Fentolamina [INN-Spanish]; Phentolamine (INN); Phentolamine [INN:BAN]; Phentolamine, methyl sulfonate; Phentolaminum [INN-Latin]; Vasomax (TN); 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline; 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 5775
  ChEBI ID: CHEMBL597
  CAS Number: CAS 50-60-2
  TTD Drug ID: D01JUF
  VARIDT Drug ID: DR00754

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.45	0.00e+0	19/20 (95%)	SQLE;MSMO1;NSDHL;...
Pyruvate metabolism	2.10	0.00e+0	41/47 (87.23%)	DLD;ACAT2;ADH1B;...
Terpenoid backbone biosynthesis	2.08	0.00e+0	18/22 (81.82%)	ACAT2;IDI1;FDPS;...
Tryptophan metabolism	2.03	2.99e-3	35/42 (83.33%)	DLD;ACAT2;KYNU;...
Glycolysis / Gluconeogenesis	2.01	2.39e-3	56/67 (83.58%)	DLD;ALDH3A1;ADH1B;...
Intestinal immune network for IgA production	1.96	1.99e-3	38/48 (79.17%)	CXCL12;CD40;HLA-DPA1;...
Propanoate metabolism	1.96	1.71e-3	30/34 (88.24%)	DLD;ACAT2;SUCLA2;...
Primary immunodeficiency	1.89	2.99e-3	33/38 (86.84%)	CD40;IL7R;CD79A;...
Glyoxylate and dicarboxylate metabolism	1.89	2.66e-3	23/30 (76.67%)	DLD;ACAT2;SHMT1;...
Pentose phosphate pathway	1.74	2.99e-2	25/30 (83.33%)	G6PD;PFKL;FBP1;...
Citrate cycle (TCA cycle)	1.73	2.94e-2	30/30 (100%)	DLD;PCK1;SUCLA2;...
Systemic lupus erythematosus	1.70	4.19e-2	45/135 (33.33%)	C7;CD40;HLA-DPA1;...
Oxidative phosphorylation	1.68	4.97e-2	93/133 (69.92%)	COX17;TCIRG1;COX7B;...
Lysine degradation	1.67	4.87e-2	51/63 (80.95%)	DLD;ACAT2;MECOM;...
Sulfur metabolism	-1.88	2.05e-2	9/10 (90%)	SELENBP1;ETHE1;PAPSS1
Ferroptosis	-1.91	1.64e-2	36/41 (87.8%)	SLC11A2;SLC3A2;NCOA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼