Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMXYTN9)

Drug Name
Phenmetrazine Drug Info
Synonyms
Cafilon; Defenmetrazin; Dexphenmetrazine; Fenmetrazin; Fenmetrazina; Oxazimedrine; Phenmetraline; Phenmetrazin; Phenmetrazinum; Preludin hydrochloride; A 66; Psychamine A 66; Defenmetrazin (TN); Fenmetrazin (TN); Fenmetrazina [INN-Spanish]; Oxazimedrine (TN); Phenmetraline (TN); Phenmetrazine [INN:BAN]; Phenmetrazinum [INN-Latin]; Dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine; 2-Fenyl-3-methylmorfolin; 2-Fenyl-3-methylmorfolin [Czech]; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
Therapeutic ClassAppetite Depressants
Cross-matching ID
PubChem CID
4762
ChEBI ID
CHEMBL8067
CAS Number
CAS 134-49-6
TTD Drug ID
D0M2MC
VARIDT Drug ID
DR01097

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.33 0.00e+0 34/36 (94.44%) POLE2;MCM5;PCNA;...
Systemic lupus erythematosus 1.96 3.74e-3 45/135 (33.33%) HLA-DQA1;C1R;HLA-DQB1;...
Ascorbate and aldarate metabolism 1.92 4.99e-3 15/30 (50%) UGT2B15;UGT2B28;UGDH;...
Steroid hormone biosynthesis 1.87 1.31e-2 43/61 (70.49%) UGT2B15;UGT2B28;AKR1C3;...
Mismatch repair 1.86 1.20e-2 22/23 (95.65%) PCNA;RFC3;MSH2;...
Complement and coagulation cascades 1.79 1.87e-2 76/85 (89.41%) TFPI;PLAT;CFI;...
Cell cycle 1.76 2.25e-2 110/124 (88.71%) MCM5;PCNA;MYC;...
Graft-versus-host disease 1.72 2.99e-2 32/42 (76.19%) HLA-DQA1;HLA-DQB1;HLA-DRA;...
Allograft rejection 1.69 3.74e-2 32/38 (84.21%) HLA-DQA1;HLA-DQB1;HLA-DRA;...
Base excision repair 1.67 4.49e-2 29/33 (87.88%) POLE2;PCNA;HMGB1;...
Retinol metabolism 1.66 4.63e-2 41/68 (60.29%) UGT2B15;ALDH1A3;UGT2B28;...
Amyotrophic lateral sclerosis -1.69 4.47e-2 267/364 (73.35%) PSMA1;NRBF2;PSMA7;...
Prion disease -1.70 4.28e-2 209/273 (76.56%) PSMA1;PSMA7;PSMD13;...
Pathways of neurodegeneration -1.71 4.05e-2 354/475 (74.53%) PSMD11;PSMB6;IFT57;...
Pentose phosphate pathway -1.75 3.34e-2 25/30 (83.33%) TKT;PRPS1;RPIA;...
Collecting duct acid secretion -1.98 0.00e+0 22/27 (81.48%) ATP6V1A;ATP6V1F;ATP6V1E1;...
Lysosome -1.98 0.00e+0 115/128 (89.84%) ATP6V0C;HYAL3;AP1M2;...
Fructose and mannose metabolism -2.00 0.00e+0 30/33 (90.91%) PFKFB2;ENOSF1;HK3;...
Synaptic vesicle cycle -2.02 0.00e+0 63/78 (80.77%) RAB3A;CLTCL1;ATP6V1A;...
Citrate cycle (TCA cycle) -2.06 0.00e+0 30/30 (100%) IDH3G;DLST;SDHD;...
Oxidative phosphorylation -2.12 0.00e+0 93/133 (69.92%) COX6B1;SDHD;ATP6V1A;...
Parkinson disease -2.15 0.00e+0 176/249 (70.68%) PSMD11;PSMB6;GPR37;...
Vibrio cholerae infection -2.22 0.00e+0 44/50 (88%) ACTB;ATP6V1A;ATP6V1F;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H