Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY0EKH)

Drug Name
Nemonapride Drug Info
Synonyms Emilace (TN); Nemonapride (JAN/INN); Nemonapride, (cis)-isomer
Cross-matching ID
PubChem CID
156333
ChEBI ID
CHEMBL64219
CAS Number
CAS 187139-87-3
TTD Drug ID
D0IN7I

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.01 6.20e-3 101/150 (67.33%) HSPA1A;PRPF4;PQBP1;...
One carbon pool by folate 1.90 9.30e-3 15/20 (75%) MTHFD1;SHMT1;ATIC;...
DNA replication 1.89 6.20e-3 34/36 (94.44%) FEN1;MCM7;MCM6;...
Ribosome biogenesis in eukaryotes 1.71 4.65e-2 52/108 (48.15%) NVL;BMS1;POP7;...
Human immunodeficiency virus 1 infection -1.67 2.90e-2 189/212 (89.15%) CHEK1;MAP2K6;CASP8;...
Shigellosis -1.68 2.78e-2 180/246 (73.17%) TAB2;PIK3CB;ACTR2;...
Type I diabetes mellitus -1.68 2.83e-2 38/43 (88.37%) CD28;HLA-DPA1;HLA-DPB1;...
Fc gamma R-mediated phagocytosis -1.69 2.57e-2 79/97 (81.44%) ARPC3;PIK3CB;ACTR2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.71 1.99e-2 79/89 (88.76%) CD3G;MAP2K6;PPP3R1;...
Toll-like receptor signaling pathway -1.73 1.31e-2 94/104 (90.38%) TLR4;IL12B;TOLLIP;...
Other glycan degradation -1.74 1.31e-2 13/18 (72.22%) MANBA;NEU1;HEXB;...
Salmonella infection -1.75 1.20e-2 198/249 (79.52%) RHOH;TUBB1;FLNA;...
Neutrophil extracellular trap formation -1.76 1.15e-2 101/189 (53.44%) PIK3CB;PRKCB;FPR3;...
C-type lectin receptor signaling pathway -1.76 1.20e-2 93/104 (89.42%) CASP8;CLEC7A;PPP3R1;...
IL-17 signaling pathway -1.77 1.26e-2 84/94 (89.36%) CXCL3;RELA;TNF;...
Nitrogen metabolism -1.77 1.19e-2 16/17 (94.12%) GLUL;CA12;CA2
T cell receptor signaling pathway -1.78 1.19e-2 93/104 (89.42%) MAP3K8;PPP3R1;PIK3CB;...
Ferroptosis -1.78 1.26e-2 36/41 (87.8%) PCBP1;ACSL4;ACSL6;...
Yersinia infection -1.78 1.34e-2 120/137 (87.59%) MEFV;MAPK8;ZAP70;...
Leishmaniasis -1.79 1.34e-2 67/77 (87.01%) HLA-DPA1;CR1;HLA-DPB1;...
Tuberculosis -1.81 1.08e-2 159/180 (88.33%) IFNA4;CAMK2B;IL10;...
Leukocyte transendothelial migration -1.81 1.16e-2 90/114 (78.95%) PIK3CB;PRKCB;RAP1A;...
Lysosome -1.84 8.40e-3 115/128 (89.84%) CTSE;ATP6V1H;AP3S2;...
PPAR signaling pathway -1.84 9.16e-3 66/74 (89.19%) ACSL5;APOA1;FABP6;...
Staphylococcus aureus infection -1.85 8.82e-3 72/95 (75.79%) FPR3;KRT36;KRT10;...
Mineral absorption -1.88 2.80e-3 48/60 (80%) ATOX1;ATP7A;MT1M;...
Phagosome -1.90 3.15e-3 118/152 (77.63%) SEC61G;HLA-DQB1;ATP6V1H;...
Pentose phosphate pathway -1.90 3.60e-3 25/30 (83.33%) ALDOC;PFKP;PGLS;...
Steroid biosynthesis -1.91 4.20e-3 19/20 (95%) LSS;CYP27B1;SQLE;...
TNF signaling pathway -1.91 5.04e-3 103/112 (91.96%) FADD;JAG1;MAP2K6;...
NF-kappa B signaling pathway -1.92 6.30e-3 90/104 (86.54%) CARD10;TAB2;PRKCB;...
Galactose metabolism -1.93 8.40e-3 26/31 (83.87%) LALBA;GALE;PFKP;...
Hematopoietic cell lineage -1.95 6.30e-3 90/99 (90.91%) IL1R1;CD7;GYPA;...
Osteoclast differentiation -2.04 0.00e+0 117/127 (92.13%) TYK2;CYLD;FHL2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H