Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY0UEQ)

• Drug Name: VATALANIB Drug Info
• Synonyms: Vatalanib; 212141-54-3; Vatalanib base; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK787; Pynasunate; CGP 79787; Vatalanib free base; PTK-787; Vatalanib (free base); Vatalinib; ZK-232934; CGP-79787; ZK222584; PTK/ZK; CHEMBL101253; N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine; UNII-5DX9U76296; CHEBI:90620; YCOYDOIWSSHVCK-UHFFFAOYSA-N; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine; 5DX9U76296; NCGC00181350-01; 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-; DSSTox_CID_26919
• Cross-matching ID:
  PubChem CID: 151194
  ChEBI ID: CHEMBL90620
  CAS Number: CAS 212141-54-3
  TTD Drug ID: D0P6DJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Rheumatoid arthritis	2.28	0.00e+0	78/93 (83.87%)	ICAM1;CCL20;IL6;...
Graft-versus-host disease	1.94	1.91e-2	32/42 (76.19%)	IL6;IL1A;TNF;...
Cell adhesion molecules	1.93	1.27e-2	118/148 (79.73%)	VTCN1;ICAM1;CLDN4;...
Allograft rejection	1.92	9.56e-3	32/38 (84.21%)	TNF;HLA-B;HLA-DRB1;...
D-Glutamine and D-glutamate metabolism	1.87	1.15e-2	5/5 (100%)	GLS;GLUD1;DGLUCY;...
TNF signaling pathway	1.81	2.07e-2	103/112 (91.96%)	CASP10;ICAM1;CCL20;...
Synaptic vesicle cycle	1.79	2.59e-2	63/78 (80.77%)	STX1A;SYT1;CLTA;...
Thiamine metabolism	-1.77	4.63e-2	12/15 (80%)	ALPL;AK5;AK1;...
Proteasome	-1.87	2.46e-2	44/46 (95.65%)	PSMD12;IFNG;PSMD14;...
Spliceosome	-1.91	1.05e-2	101/150 (67.33%)	HNRNPA3;RBM25;THOC1;...
Complement and coagulation cascades	-1.95	1.05e-2	76/85 (89.41%)	C3;PROS1;CFHR2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼