Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY2AH1)

Drug Name
Aminophenazone Drug Info
Synonyms
AMINOPYRINE; Amidazofen; Amidazophen; Amidazophene; Amidofebrin; Amidofen; Amidophen; Amidophenazone; Amidopyrazoline; Amidopyrin; Amidopyrine; Aminofenazone; Aminophenazon; Aminopyrin; Anafebrina; Brufaneuxol; Dereuma; Dimapyrin; Dimethylaminoantipyrine; Dimethylaminoazophene; Dimethylaminophenazone; Dipirin; Dipyrin; Dipyrine; Eufibron; Febrinina; Febron; Hyparon; Itamidone; Mamallet-A; Novamidon; Piramidon; Pirazon; Piridol; Piromidina; Polinalin; Pyradone; Pyramidon; Pyramidone; aminophenazone; 4-Dimethylaminoantipyrine; 58-15-1
Cross-matching ID
PubChem CID
6009
ChEBI ID
CHEMBL288470
CAS Number
CAS 58-15-1
INTEDE Drug ID
DR0089

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
mRNA surveillance pathway 1.82 4.43e-2 71/98 (72.45%) FUS;PPP2R1B;PPP2R5C;...
Focal adhesion 1.72 4.91e-2 180/201 (89.55%) COL1A1;PDGFRA;IGF1R;...
Prostate cancer 1.71 4.61e-2 93/97 (95.88%) PDGFRA;IGF1R;E2F3;...
Retrograde endocannabinoid signaling -1.67 4.62e-2 118/148 (79.73%) GABRA1;GNAO1;PLCB1;...
Prion disease -1.68 4.65e-2 209/273 (76.56%) ATP5F1D;PSMD9;GRIN2C;...
Intestinal immune network for IgA production -1.70 4.00e-2 38/48 (79.17%) HLA-DQA1;PIGR;CXCL12;...
Rheumatoid arthritis -1.84 6.61e-3 78/93 (83.87%) TNFRSF11A;LTB;FOS;...
Parkinson disease -1.86 6.04e-3 176/249 (70.68%) PSMD8;COX7C;ATP5F1D;...
Asthma -1.86 5.29e-3 25/31 (80.65%) HLA-DQA1;FCER1A;PRG2;...
RNA polymerase -1.93 4.23e-3 23/31 (74.19%) POLR2D;POLR3G;POLR2F;...
Mineral absorption -2.04 0.00e+0 48/60 (80%) HMOX2;FTL;ATOX1;...
Pentose and glucuronate interconversions -2.07 0.00e+0 17/34 (50%) RPE;CRYL1;UGT2A3;...
Oxidative phosphorylation -2.15 0.00e+0 93/133 (69.92%) ATP4B;COX6A2;NDUFA1;...
Hematopoietic cell lineage -2.15 0.00e+0 90/99 (90.91%) IL1A;MS4A1;CD59;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H